Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse
The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to absti...
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| Veröffentlicht in: | The international journal of neuropsychopharmacology 2015-02, Vol.18 (3), p.pyu059-pyu059 |
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| creator | O'Neill, Joseph Tobias, Marc C Hudkins, Matthew London, Edythe D |
| description | The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study further explored this phenomenon.
We measured glutamate+glutamine in additional cortical regions (midline posterior cingulate, midline precuneus, and bilateral inferior frontal cortex) putatively affected by methamphetamine. We examined the relationship between glutamate+glutamine in each region with duration of methamphetamine abuse as well as the depressive symptoms of early abstinence. Magnetic resonance spectroscopic imaging was acquired at 1.5 T from a methamphetamine group of 44 adults who had chronically abused methamphetamine and a control group of 23 age-, sex-, and tobacco smoking-matched healthy volunteers. Participants in the methamphetamine group were studied as inpatients during the first week of abstinence from the drug and were not receiving treatment.
In the methamphetamine group, small but significant (5-15%, P |
| doi_str_mv | 10.1093/ijnp/pyu059 |
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We measured glutamate+glutamine in additional cortical regions (midline posterior cingulate, midline precuneus, and bilateral inferior frontal cortex) putatively affected by methamphetamine. We examined the relationship between glutamate+glutamine in each region with duration of methamphetamine abuse as well as the depressive symptoms of early abstinence. Magnetic resonance spectroscopic imaging was acquired at 1.5 T from a methamphetamine group of 44 adults who had chronically abused methamphetamine and a control group of 23 age-, sex-, and tobacco smoking-matched healthy volunteers. Participants in the methamphetamine group were studied as inpatients during the first week of abstinence from the drug and were not receiving treatment.
In the methamphetamine group, small but significant (5-15%, P<.05) decrements (vs control) in glutamate+glutamine were observed in posterior cingulate, precuneus, and right inferior frontal cortex; glutamate+glutamine in posterior cingulate was negatively correlated (P<.05) with years of methamphetamine abuse. The Beck Depression Inventory score was negatively correlated (P<.005) with glutamate+glutamine in right inferior frontal cortex.
Our findings support the idea that glutamatergic metabolism is downregulated in early abstinence in multiple cortical regions. The extent of downregulation may vary with length of abuse and may be associated with severity of depressive symptoms emergent in early recovery.</description><identifier>ISSN: 1461-1457</identifier><identifier>EISSN: 1469-5111</identifier><identifier>DOI: 10.1093/ijnp/pyu059</identifier><identifier>PMID: 25522400</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adult ; Amphetamine-Related Disorders - metabolism ; Brain - metabolism ; Case-Control Studies ; Female ; Glutamic Acid - metabolism ; Glutamine - metabolism ; Humans ; Image Processing, Computer-Assisted ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Protons ; Statistics as Topic ; Substance-Related Disorders - metabolism ; Young Adult</subject><ispartof>The international journal of neuropsychopharmacology, 2015-02, Vol.18 (3), p.pyu059-pyu059</ispartof><rights>The Author 2015. Published by Oxford University Press on behalf of CINP.</rights><rights>The Author 2015. Published by Oxford University Press on behalf of CINP. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-8d75321455048582cd788148cab5b74574a9d86e4622c8c9a762ab4c6d0554023</citedby><cites>FETCH-LOGICAL-c484t-8d75321455048582cd788148cab5b74574a9d86e4622c8c9a762ab4c6d0554023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360253/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360253/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25522400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Tobias, Marc C</creatorcontrib><creatorcontrib>Hudkins, Matthew</creatorcontrib><creatorcontrib>London, Edythe D</creatorcontrib><title>Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse</title><title>The international journal of neuropsychopharmacology</title><addtitle>Int J Neuropsychopharmacol</addtitle><description>The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study further explored this phenomenon.
We measured glutamate+glutamine in additional cortical regions (midline posterior cingulate, midline precuneus, and bilateral inferior frontal cortex) putatively affected by methamphetamine. We examined the relationship between glutamate+glutamine in each region with duration of methamphetamine abuse as well as the depressive symptoms of early abstinence. Magnetic resonance spectroscopic imaging was acquired at 1.5 T from a methamphetamine group of 44 adults who had chronically abused methamphetamine and a control group of 23 age-, sex-, and tobacco smoking-matched healthy volunteers. Participants in the methamphetamine group were studied as inpatients during the first week of abstinence from the drug and were not receiving treatment.
In the methamphetamine group, small but significant (5-15%, P<.05) decrements (vs control) in glutamate+glutamine were observed in posterior cingulate, precuneus, and right inferior frontal cortex; glutamate+glutamine in posterior cingulate was negatively correlated (P<.05) with years of methamphetamine abuse. The Beck Depression Inventory score was negatively correlated (P<.005) with glutamate+glutamine in right inferior frontal cortex.
Our findings support the idea that glutamatergic metabolism is downregulated in early abstinence in multiple cortical regions. The extent of downregulation may vary with length of abuse and may be associated with severity of depressive symptoms emergent in early recovery.</description><subject>Adult</subject><subject>Amphetamine-Related Disorders - metabolism</subject><subject>Brain - metabolism</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Glutamic Acid - metabolism</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Magnetic Resonance Imaging</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Protons</subject><subject>Statistics as Topic</subject><subject>Substance-Related Disorders - metabolism</subject><subject>Young Adult</subject><issn>1461-1457</issn><issn>1469-5111</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc9LwzAcxYMobk5P3qVHQeqSNEnTiyBDpzDwogdPIU2zLaNNa34I--_NnA49fQPfz3vfRx4AlwjeIlgVU7Oxw3TYRkirIzBGhFU5RQgdf79RjggtR-DM-w2EmNCCnYIRphRjAuEYvM_bGGQng3YrozKro-s7HWTdtyZonzXRGbvKtHTtNpO1D8Zqq3S2TFim1q63SZUEa9kN66Tr0j5x0etzcLKUrdcXP3MC3h4fXmdP-eJl_jy7X-SKcBJy3pS0wCkkhYRTjlVTco4IV7KmdZmyE1k1nGnCMFZcVbJkWNZEsQZSSiAuJuBu7zvEutON0jY42YrBmU66reilEf831qzFqv8UpGAQ0yIZXP8YuP4jah9EZ7zSbSut7qMXqGS0KlHFaUJv9qhyvfdOLw9nEBS7MsSuDLEvI9FXf5Md2N_fL74AjbaJDQ</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>O'Neill, Joseph</creator><creator>Tobias, Marc C</creator><creator>Hudkins, Matthew</creator><creator>London, Edythe D</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse</title><author>O'Neill, Joseph ; Tobias, Marc C ; Hudkins, Matthew ; London, Edythe D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-8d75321455048582cd788148cab5b74574a9d86e4622c8c9a762ab4c6d0554023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Amphetamine-Related Disorders - metabolism</topic><topic>Brain - metabolism</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Glutamic Acid - metabolism</topic><topic>Glutamine - metabolism</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Magnetic Resonance Imaging</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Protons</topic><topic>Statistics as Topic</topic><topic>Substance-Related Disorders - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'Neill, Joseph</creatorcontrib><creatorcontrib>Tobias, Marc C</creatorcontrib><creatorcontrib>Hudkins, Matthew</creatorcontrib><creatorcontrib>London, Edythe D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The international journal of neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'Neill, Joseph</au><au>Tobias, Marc C</au><au>Hudkins, Matthew</au><au>London, Edythe D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse</atitle><jtitle>The international journal of neuropsychopharmacology</jtitle><addtitle>Int J Neuropsychopharmacol</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>18</volume><issue>3</issue><spage>pyu059</spage><epage>pyu059</epage><pages>pyu059-pyu059</pages><issn>1461-1457</issn><eissn>1469-5111</eissn><abstract>The acute phase of abstinence from methamphetamine abuse is critical for rehabilitation success. Proton magnetic resonance spectroscopy has detected below-normal levels of glutamate+glutamine in anterior middle cingulate of chronic methamphetamine abusers during early abstinence, attributed to abstinence-induced downregulation of the glutamatergic systems in the brain. This study further explored this phenomenon.
We measured glutamate+glutamine in additional cortical regions (midline posterior cingulate, midline precuneus, and bilateral inferior frontal cortex) putatively affected by methamphetamine. We examined the relationship between glutamate+glutamine in each region with duration of methamphetamine abuse as well as the depressive symptoms of early abstinence. Magnetic resonance spectroscopic imaging was acquired at 1.5 T from a methamphetamine group of 44 adults who had chronically abused methamphetamine and a control group of 23 age-, sex-, and tobacco smoking-matched healthy volunteers. Participants in the methamphetamine group were studied as inpatients during the first week of abstinence from the drug and were not receiving treatment.
In the methamphetamine group, small but significant (5-15%, P<.05) decrements (vs control) in glutamate+glutamine were observed in posterior cingulate, precuneus, and right inferior frontal cortex; glutamate+glutamine in posterior cingulate was negatively correlated (P<.05) with years of methamphetamine abuse. The Beck Depression Inventory score was negatively correlated (P<.005) with glutamate+glutamine in right inferior frontal cortex.
Our findings support the idea that glutamatergic metabolism is downregulated in early abstinence in multiple cortical regions. The extent of downregulation may vary with length of abuse and may be associated with severity of depressive symptoms emergent in early recovery.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>25522400</pmid><doi>10.1093/ijnp/pyu059</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Amphetamine-Related Disorders - metabolism Brain - metabolism Case-Control Studies Female Glutamic Acid - metabolism Glutamine - metabolism Humans Image Processing, Computer-Assisted Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Male Protons Statistics as Topic Substance-Related Disorders - metabolism Young Adult |
| title | Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse |
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