A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate
Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection...
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| Veröffentlicht in: | Heredity 2015-04, Vol.114 (4), p.419-427 |
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| creator | Wone, B W M Madsen, P Donovan, E R Labocha, M K Sears, M W Downs, C J Sorensen, D A Hayes, J P |
| description | Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR, and BMR was slightly, but not significantly, higher (2.5%). Compared with controls, MMR was significantly higher (5.3%) in antagonistically selected lines, and BMR was slightly, but not significantly, lower (4.2%). Analysis of breeding values revealed no positive genetic trend for elevated BMR in high-MMR lines. A weak positive genetic correlation was detected between MMR and BMR. That weak positive genetic correlation supports the aerobic capacity model for the evolution of endothermy in the sense that it fails to falsify a key model assumption. Overall, the results suggest that at least in these mice there is significant capacity for independent evolution of metabolic traits. Whether that is true in the ancestral animals that evolved endothermy remains an important but unanswered question. |
| doi_str_mv | 10.1038/hdy.2014.122 |
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Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR, and BMR was slightly, but not significantly, higher (2.5%). Compared with controls, MMR was significantly higher (5.3%) in antagonistically selected lines, and BMR was slightly, but not significantly, lower (4.2%). Analysis of breeding values revealed no positive genetic trend for elevated BMR in high-MMR lines. A weak positive genetic correlation was detected between MMR and BMR. That weak positive genetic correlation supports the aerobic capacity model for the evolution of endothermy in the sense that it fails to falsify a key model assumption. Overall, the results suggest that at least in these mice there is significant capacity for independent evolution of metabolic traits. Whether that is true in the ancestral animals that evolved endothermy remains an important but unanswered question.</description><identifier>ISSN: 0018-067X</identifier><identifier>EISSN: 1365-2540</identifier><identifier>DOI: 10.1038/hdy.2014.122</identifier><identifier>PMID: 25604947</identifier><identifier>CODEN: HDTYAT</identifier><language>eng</language><publisher>England: Springer Nature B.V</publisher><subject>Animals ; Basal Metabolism - genetics ; Bayes Theorem ; Biological Evolution ; Body mass ; Body Weight ; Breeding ; Evolution ; Female ; Male ; Metabolism ; Mice ; Original ; Phenotype ; Rodents ; Selection, Genetic</subject><ispartof>Heredity, 2015-04, Vol.114 (4), p.419-427</ispartof><rights>Copyright Nature Publishing Group Apr 2015</rights><rights>Copyright © 2015 The Genetics Society 2015 The Genetics Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-e1f7b47b3ef87415bffd7f9589d99e8e91dd28934ae8274fcbe203ea1d1cace53</citedby><cites>FETCH-LOGICAL-c445t-e1f7b47b3ef87415bffd7f9589d99e8e91dd28934ae8274fcbe203ea1d1cace53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359981/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359981/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25604947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wone, B W M</creatorcontrib><creatorcontrib>Madsen, P</creatorcontrib><creatorcontrib>Donovan, E R</creatorcontrib><creatorcontrib>Labocha, M K</creatorcontrib><creatorcontrib>Sears, M W</creatorcontrib><creatorcontrib>Downs, C J</creatorcontrib><creatorcontrib>Sorensen, D A</creatorcontrib><creatorcontrib>Hayes, J P</creatorcontrib><title>A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate</title><title>Heredity</title><addtitle>Heredity (Edinb)</addtitle><description>Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR, and BMR was slightly, but not significantly, higher (2.5%). Compared with controls, MMR was significantly higher (5.3%) in antagonistically selected lines, and BMR was slightly, but not significantly, lower (4.2%). Analysis of breeding values revealed no positive genetic trend for elevated BMR in high-MMR lines. A weak positive genetic correlation was detected between MMR and BMR. That weak positive genetic correlation supports the aerobic capacity model for the evolution of endothermy in the sense that it fails to falsify a key model assumption. Overall, the results suggest that at least in these mice there is significant capacity for independent evolution of metabolic traits. Whether that is true in the ancestral animals that evolved endothermy remains an important but unanswered question.</description><subject>Animals</subject><subject>Basal Metabolism - genetics</subject><subject>Bayes Theorem</subject><subject>Biological Evolution</subject><subject>Body mass</subject><subject>Body Weight</subject><subject>Breeding</subject><subject>Evolution</subject><subject>Female</subject><subject>Male</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Original</subject><subject>Phenotype</subject><subject>Rodents</subject><subject>Selection, Genetic</subject><issn>0018-067X</issn><issn>1365-2540</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkstrFTEUxoMo9lrduZaAGxfONa-ZJBuhlPqAghsFdyGTnOlNmUmuSUbtqv-6ubTW10YICZz88p2ccz6EnlKypYSrVzt_tWWEii1l7B7aUD70HesFuY82hFDVkUF-PkKPSrkkhHDJ9EN0xPqBCC3kBl2f4FJzihc4Q9mnWADXhAvM4GpIEbe12FK6ED3soW2xtsD3sNgZL1DtmObgcLYV8LdQd2mt2GKXcoa5xfwv1RDxaMs_rx6jB5OdCzy5PY_RpzdnH0_fdecf3r4_PTnvnBB97YBOchRy5DApKWg_TpOXk-6V9lqDAk29Z0pzYUExKSY3AiMcLPXUWQc9P0avb3T367iAd62ObGezz62SfGWSDebPmxh25iJ9NYL3WivaBF7cCuT0ZYVSzRKKg3m2EdJaDB0GxYRujf8flA1cDoI39Plf6GVac2ydOFBUqzavQ-6XN5TLqZQM092_KTEHE5hmAnMwgWkmaPiz32u9g39Onf8ARPew7A</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Wone, B W M</creator><creator>Madsen, P</creator><creator>Donovan, E R</creator><creator>Labocha, M K</creator><creator>Sears, M W</creator><creator>Downs, C J</creator><creator>Sorensen, D A</creator><creator>Hayes, J P</creator><general>Springer Nature B.V</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SN</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150401</creationdate><title>A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate</title><author>Wone, B W M ; Madsen, P ; Donovan, E R ; Labocha, M K ; Sears, M W ; Downs, C J ; Sorensen, D A ; Hayes, J P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-e1f7b47b3ef87415bffd7f9589d99e8e91dd28934ae8274fcbe203ea1d1cace53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Basal Metabolism - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Heredity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wone, B W M</au><au>Madsen, P</au><au>Donovan, E R</au><au>Labocha, M K</au><au>Sears, M W</au><au>Downs, C J</au><au>Sorensen, D A</au><au>Hayes, J P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate</atitle><jtitle>Heredity</jtitle><addtitle>Heredity (Edinb)</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>114</volume><issue>4</issue><spage>419</spage><epage>427</epage><pages>419-427</pages><issn>0018-067X</issn><eissn>1365-2540</eissn><coden>HDTYAT</coden><abstract>Metabolic rates are correlated with many aspects of ecology, but how selection on different aspects of metabolic rates affects their mutual evolution is poorly understood. Using laboratory mice, we artificially selected for high maximal mass-independent metabolic rate (MMR) without direct selection on mass-independent basal metabolic rate (BMR). Then we tested for responses to selection in MMR and correlated responses to selection in BMR. In other lines, we antagonistically selected for mice with a combination of high mass-independent MMR and low mass-independent BMR. All selection protocols and data analyses included body mass as a covariate, so effects of selection on the metabolic rates are mass adjusted (that is, independent of effects of body mass). The selection lasted eight generations. Compared with controls, MMR was significantly higher (11.2%) in lines selected for increased MMR, and BMR was slightly, but not significantly, higher (2.5%). Compared with controls, MMR was significantly higher (5.3%) in antagonistically selected lines, and BMR was slightly, but not significantly, lower (4.2%). Analysis of breeding values revealed no positive genetic trend for elevated BMR in high-MMR lines. A weak positive genetic correlation was detected between MMR and BMR. That weak positive genetic correlation supports the aerobic capacity model for the evolution of endothermy in the sense that it fails to falsify a key model assumption. Overall, the results suggest that at least in these mice there is significant capacity for independent evolution of metabolic traits. Whether that is true in the ancestral animals that evolved endothermy remains an important but unanswered question.</abstract><cop>England</cop><pub>Springer Nature B.V</pub><pmid>25604947</pmid><doi>10.1038/hdy.2014.122</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Basal Metabolism - genetics Bayes Theorem Biological Evolution Body mass Body Weight Breeding Evolution Female Male Metabolism Mice Original Phenotype Rodents Selection, Genetic |
| title | A strong response to selection on mass-independent maximal metabolic rate without a correlated response in basal metabolic rate |
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