Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines

Squamous cell carcinoma (SCC) is the most common type of tongue and larynx cancer and a common type of lung cancer. In this study, we attempted to specifically evaluate the signaling pathway underlying HGF/Met induced EGFR ligand release in SSCs. The Met proto-oncogene encodes for a tyrosine kinase...

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Veröffentlicht in:	Molecular cancer 2015-03, Vol.14 (1), p.54-54, Article 54
Hauptverfasser:	Gusenbauer, Simone, Zanucco, Emanuele, Knyazev, Pjotr, Ullrich, Axel
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphiregulin - metabolism Biotechnology industry Cancer Carcinoma, Squamous Cell - metabolism Care and treatment Cell Communication Cell Line, Tumor Computer software industry Endothelial Cells - metabolism Genetic aspects Hepatocyte Growth Factor - pharmacology Humans MAP Kinase Signaling System - drug effects Medical research Medicine, Experimental Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 Models, Biological Paracrine Communication Physiological aspects Protein Binding Proto-Oncogene Proteins c-met - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Risk factors Short Communication Squamous cell carcinoma Tyrosine
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