Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?
Summary Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gon...
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| Veröffentlicht in: | Parasite immunology 2015-03, Vol.37 (3), p.127-140 |
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| creator | English, E. D. Adomako‐Ankomah, Y. Boyle, J. P. |
| description | Summary
Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gondii compared to some of its nearest apicomplexan relatives (Hammondia hammondi and Neospora caninum) is unknown. These unique features include distinct dissemination characteristics in vivo and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for T. gondii, H. hammondi, and N. caninum. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key T. gondii effectors in these three species. |
| doi_str_mv | 10.1111/pim.12166 |
| format | Article |
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Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gondii compared to some of its nearest apicomplexan relatives (Hammondia hammondi and Neospora caninum) is unknown. These unique features include distinct dissemination characteristics in vivo and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for T. gondii, H. hammondi, and N. caninum. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key T. gondii effectors in these three species.</description><identifier>ISSN: 0141-9838</identifier><identifier>EISSN: 1365-3024</identifier><identifier>DOI: 10.1111/pim.12166</identifier><identifier>PMID: 25655311</identifier><language>eng</language><publisher>England: BlackWell Publishing Ltd</publisher><subject>Animals ; Base Sequence ; Coccidiosis - immunology ; Coccidiosis - parasitology ; comparative genomics ; Disease Models, Animal ; host range expansion ; Host Specificity ; Host-Parasite Interactions ; Mice ; Neospora - physiology ; Protozoan Proteins - genetics ; Protozoan Proteins - immunology ; Protozoan Proteins - physiology ; Review ; Sarcocystidae - physiology ; Toxoplasma - pathogenicity ; Toxoplasma - physiology ; Toxoplasmosis - immunology ; Toxoplasmosis - parasitology ; Virulence ; Virulence Factors - genetics ; Virulence Factors - immunology ; Virulence Factors - physiology</subject><ispartof>Parasite immunology, 2015-03, Vol.37 (3), p.127-140</ispartof><rights>2014 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2014 The Authors. Parasite Immunology published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2015 John Wiley & Sons Ltd 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3806-79a361d3b7c912360f212bef25a83e3aed565807ae0ac41cf36ed567d8af0c293</citedby><cites>FETCH-LOGICAL-c3806-79a361d3b7c912360f212bef25a83e3aed565807ae0ac41cf36ed567d8af0c293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpim.12166$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpim.12166$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25655311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>English, E. D.</creatorcontrib><creatorcontrib>Adomako‐Ankomah, Y.</creatorcontrib><creatorcontrib>Boyle, J. P.</creatorcontrib><title>Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?</title><title>Parasite immunology</title><addtitle>Parasite Immunol</addtitle><description>Summary
Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gondii compared to some of its nearest apicomplexan relatives (Hammondia hammondi and Neospora caninum) is unknown. These unique features include distinct dissemination characteristics in vivo and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for T. gondii, H. hammondi, and N. caninum. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key T. gondii effectors in these three species.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Coccidiosis - immunology</subject><subject>Coccidiosis - parasitology</subject><subject>comparative genomics</subject><subject>Disease Models, Animal</subject><subject>host range expansion</subject><subject>Host Specificity</subject><subject>Host-Parasite Interactions</subject><subject>Mice</subject><subject>Neospora - physiology</subject><subject>Protozoan Proteins - genetics</subject><subject>Protozoan Proteins - immunology</subject><subject>Protozoan Proteins - physiology</subject><subject>Review</subject><subject>Sarcocystidae - physiology</subject><subject>Toxoplasma - pathogenicity</subject><subject>Toxoplasma - physiology</subject><subject>Toxoplasmosis - immunology</subject><subject>Toxoplasmosis - parasitology</subject><subject>Virulence</subject><subject>Virulence Factors - genetics</subject><subject>Virulence Factors - immunology</subject><subject>Virulence Factors - physiology</subject><issn>0141-9838</issn><issn>1365-3024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kU1P3DAQhq0KVBbaQ_8A8hEOAX8kTtIDCCEKSFStVHq2Zp3xrlFiBztLy7-vlwVUDvhiyfP4mdG8hHzh7Ijnczy64YgLrtQHMuNSVYVkotwiM8ZLXrSNbHbIbkp3jHEplPxIdkSlqkpyPiPuF5qIE3YUrUUzhZio8_Q2_A1jD2kAugi-c46C72jEHtZoGtE4TF9pl3_GwXnwU6LB0mVIE43gF_jEjzAtwwI9JpdOP5FtC33Cz8_3Hvn97eL2_Kq4-XF5fX52UxjZMFXULUjFOzmvTcuFVMwKLuZoRQWNRAnY5dkbVgMyMCU3Vqr1U901YJkRrdwjJxvvuJoP2Bn0U4Rej9ENEB91AKffVrxb6kV40KWsWsaqLDh4FsRwv8I06cElg30PHsMqaZ53V4tKqDKjhxvUxJBSRPvahjO9jkbnaPRTNJnd_3-uV_Iliwwcb4A_rsfH90365_X3jfIf9Uya2Q</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>English, E. D.</creator><creator>Adomako‐Ankomah, Y.</creator><creator>Boyle, J. P.</creator><general>BlackWell Publishing Ltd</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201503</creationdate><title>Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?</title><author>English, E. D. ; Adomako‐Ankomah, Y. ; Boyle, J. P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3806-79a361d3b7c912360f212bef25a83e3aed565807ae0ac41cf36ed567d8af0c293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Coccidiosis - immunology</topic><topic>Coccidiosis - parasitology</topic><topic>comparative genomics</topic><topic>Disease Models, Animal</topic><topic>host range expansion</topic><topic>Host Specificity</topic><topic>Host-Parasite Interactions</topic><topic>Mice</topic><topic>Neospora - physiology</topic><topic>Protozoan Proteins - genetics</topic><topic>Protozoan Proteins - immunology</topic><topic>Protozoan Proteins - physiology</topic><topic>Review</topic><topic>Sarcocystidae - physiology</topic><topic>Toxoplasma - pathogenicity</topic><topic>Toxoplasma - physiology</topic><topic>Toxoplasmosis - immunology</topic><topic>Toxoplasmosis - parasitology</topic><topic>Virulence</topic><topic>Virulence Factors - genetics</topic><topic>Virulence Factors - immunology</topic><topic>Virulence Factors - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>English, E. D.</creatorcontrib><creatorcontrib>Adomako‐Ankomah, Y.</creatorcontrib><creatorcontrib>Boyle, J. P.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Parasite immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>English, E. D.</au><au>Adomako‐Ankomah, Y.</au><au>Boyle, J. P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis?</atitle><jtitle>Parasite immunology</jtitle><addtitle>Parasite Immunol</addtitle><date>2015-03</date><risdate>2015</risdate><volume>37</volume><issue>3</issue><spage>127</spage><epage>140</epage><pages>127-140</pages><issn>0141-9838</issn><eissn>1365-3024</eissn><abstract>Summary
Recent years have witnessed the discovery of a number of secreted proteins in Toxoplasma gondii that play important roles in host–pathogen interactions and parasite virulence, particularly in the mouse model. However, the role that these proteins play in driving the unique features of T. gondii compared to some of its nearest apicomplexan relatives (Hammondia hammondi and Neospora caninum) is unknown. These unique features include distinct dissemination characteristics in vivo and a vast host range. In this review we comprehensively survey what is known about disease outcome, the host response and host range for T. gondii, H. hammondi, and N. caninum. We then review what is presently known about recently identified secreted virulence effectors in these three genetically related, but phenotypically distinct, species. Finally we exploit the existence of genome sequences for these three organisms and discuss what is known about the presence, and functionality, of key T. gondii effectors in these three species.</abstract><cop>England</cop><pub>BlackWell Publishing Ltd</pub><pmid>25655311</pmid><doi>10.1111/pim.12166</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Free Content; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via Wiley Online Library; Alma/SFX Local Collection |
| subjects | Animals Base Sequence Coccidiosis - immunology Coccidiosis - parasitology comparative genomics Disease Models, Animal host range expansion Host Specificity Host-Parasite Interactions Mice Neospora - physiology Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Proteins - physiology Review Sarcocystidae - physiology Toxoplasma - pathogenicity Toxoplasma - physiology Toxoplasmosis - immunology Toxoplasmosis - parasitology Virulence Virulence Factors - genetics Virulence Factors - immunology Virulence Factors - physiology |
| title | Secreted effectors in Toxoplasma gondii and related species: determinants of host range and pathogenesis? |
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