Protein Kinase Ymr291w/Tda1 Is Essential for Glucose Signaling in Saccharomyces cerevisiae on the Level of Hexokinase Isoenzyme ScHxk2 Phosphorylation

The enzyme ScHxk2 of Saccharomyces cerevisiae is a dual-function hexokinase that besides its catalytic role in glycolysis is involved in the transcriptional regulation of glucose-repressible genes. Relief from glucose repression is accompanied by the phosphorylation of the nuclear fraction of ScHxk2...

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Veröffentlicht in:	The Journal of biological chemistry 2015-03, Vol.290 (10), p.6243-6255
Hauptverfasser:	Kaps, Sonja, Kettner, Karina, Migotti, Rebekka, Kanashova, Tamara, Krause, Udo, Rödel, Gerhard, Dittmar, Gunnar, Kriegel, Thomas M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Gene Expression Regulation, Fungal Glucose - metabolism Glycolysis Hexokinase Hexokinase - biosynthesis Hexokinase - genetics Hexokinase - metabolism Isoenzymes - genetics Kluyveromyces Kluyveromyces lactis Phosphorylation Protein Kinase A (PKA) Protein-Serine-Threonine Kinases - biosynthesis Protein-Serine-Threonine Kinases - genetics Saccharomyces cerevisiae Saccharomyces cerevisiae Proteins - biosynthesis Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sch9 ScHxk2 Serine - genetics Signal Transduction Signal Transduction - genetics Signaling Snf1 Substrate Specificity Ymr291w/Tda1
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