Lesion search and recognition by thymine DNA glycosylase revealed by single molecule imaging

The ability of DNA glycosylases to rapidly and efficiently detect lesions among a vast excess of nondamaged DNA bases is vitally important in base excision repair (BER). Here, we use single molecule imaging by atomic force microscopy (AFM) supported by a 2-aminopurine fluorescence base flipping assa...

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Veröffentlicht in:	Nucleic acids research 2015-03, Vol.43 (5), p.2716-2729
Hauptverfasser:	Buechner, Claudia N, Maiti, Atanu, Drohat, Alexander C, Tessmer, Ingrid
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine - metabolism DNA - chemistry DNA - genetics DNA - metabolism DNA Damage DNA Glycosylases - metabolism DNA Repair Genome Integrity, Repair and Guanine - analogs & derivatives Guanine - metabolism Humans Microscopy, Atomic Force Mutation Nucleic Acid Conformation Substrate Specificity Thymine DNA Glycosylase - metabolism
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