Protein Quality Control under Oxidative Stress Conditions

Accumulation of reactive oxygen and chlorine species (RO/CS) is generally regarded to be a toxic and highly undesirable event, which serves as contributing factor in aging and many age-related diseases. However, it is also put to excellent use during host defense, when high levels of RO/CS are produ...

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Veröffentlicht in:	Journal of molecular biology 2015-04, Vol.427 (7), p.1549-1563
Hauptverfasser:	Dahl, Jan-Ulrik, Gray, Michael J., Jakob, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosinetriphosphatase adverse effects Animals Anti-Infective Agents - metabolism bacteria bacterial colonization chlorine Chlorine Compounds - toxicity disulfide bond formation Escherichia coli host-pathogen relationships Humans inflammation mammals molecular chaperone N-chlorination Oxidation-Reduction oxidative stress Oxidative Stress - physiology oxygen Protein Aggregates - physiology protein aggregation Protein Unfolding Proteins - chemistry Proteins - metabolism proteome quality control Reactive Oxygen Species - metabolism Reactive Oxygen Species - pharmacology stress tolerance toxicity yeasts
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