Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV
The relationships between HIV infection, monocyte activation, and endothelial colony forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14 + CD16 + ), and non-classical monocytes (CD14 dim CD16 ++ ) levels in HIV-infected participants virologically-suppressed on antiretro...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2015-04, Vol.68 (5), p.550-553 |
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| container_title | Journal of acquired immune deficiency syndromes (1999) |
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| creator | Hays, Travis R. Mund, Julie A. Liu, Ziyue Case, Jamie Ingram, David A. Gupta, Samir K. |
| description | The relationships between HIV infection, monocyte activation, and endothelial colony forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14
+
CD16
+
), and non-classical monocytes (CD14
dim
CD16
++
) levels in HIV-infected participants virologically-suppressed on antiretroviral therapy, HIV-infected treatment-naïve participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected, virologically-suppressed group compared to the uninfected controls. CD14
+
CD16
+
percentages (but not CD14
dim
CD16
++
cells) were significantly higher in both HIV-infected groups vs uninfected controls. In the HIV-infected groups, ECFCs and CD14
+
CD16
+
intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV. |
| doi_str_mv | 10.1097/QAI.0000000000000506 |
| format | Article |
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+
CD16
+
), and non-classical monocytes (CD14
dim
CD16
++
) levels in HIV-infected participants virologically-suppressed on antiretroviral therapy, HIV-infected treatment-naïve participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected, virologically-suppressed group compared to the uninfected controls. CD14
+
CD16
+
percentages (but not CD14
dim
CD16
++
cells) were significantly higher in both HIV-infected groups vs uninfected controls. In the HIV-infected groups, ECFCs and CD14
+
CD16
+
intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0000000000000506</identifier><identifier>PMID: 25564108</identifier><language>eng</language><ispartof>Journal of acquired immune deficiency syndromes (1999), 2015-04, Vol.68 (5), p.550-553</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Hays, Travis R.</creatorcontrib><creatorcontrib>Mund, Julie A.</creatorcontrib><creatorcontrib>Liu, Ziyue</creatorcontrib><creatorcontrib>Case, Jamie</creatorcontrib><creatorcontrib>Ingram, David A.</creatorcontrib><creatorcontrib>Gupta, Samir K.</creatorcontrib><title>Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV</title><title>Journal of acquired immune deficiency syndromes (1999)</title><description>The relationships between HIV infection, monocyte activation, and endothelial colony forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14
+
CD16
+
), and non-classical monocytes (CD14
dim
CD16
++
) levels in HIV-infected participants virologically-suppressed on antiretroviral therapy, HIV-infected treatment-naïve participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected, virologically-suppressed group compared to the uninfected controls. CD14
+
CD16
+
percentages (but not CD14
dim
CD16
++
cells) were significantly higher in both HIV-infected groups vs uninfected controls. In the HIV-infected groups, ECFCs and CD14
+
CD16
+
intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.</description><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpVjstKw0AYhQdRbK2-gYt5gdR_7slGqKG1gYoI6jZM5tJGJjMliULe3oIu9GzOBwc-DkK3BJYECnX3sqqW8DcC5Bmak4LzTOU5Pz-xoCLjhIkZuhqGDwAiOS8u0YwKITmBfI4e1tGm8eBCqwMuU0hxwpvUd23c49KFMGAdLa6iD7rr9Jj6CT-lmMw0ugG3EW-r92t04XUY3M1vL9DbZv1abrPd82NVrnbZkRIYM08ozQm3RkiVNwX1RDjj7OkQk6BAgjfUa7AgmKHUSO60kDkoL2xjmVZsge5_vMfPpnPWuDj2OtTHvu10P9VJt_X_JbaHep--as6EEkyxbxwlWVE</recordid><startdate>20150415</startdate><enddate>20150415</enddate><creator>Hays, Travis R.</creator><creator>Mund, Julie A.</creator><creator>Liu, Ziyue</creator><creator>Case, Jamie</creator><creator>Ingram, David A.</creator><creator>Gupta, Samir K.</creator><scope>5PM</scope></search><sort><creationdate>20150415</creationdate><title>Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV</title><author>Hays, Travis R. ; Mund, Julie A. ; Liu, Ziyue ; Case, Jamie ; Ingram, David A. ; Gupta, Samir K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p210t-f122814dc5678b92f15eced4493607060fc2fa0d053c22c64ea56807f5dbd3a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hays, Travis R.</creatorcontrib><creatorcontrib>Mund, Julie A.</creatorcontrib><creatorcontrib>Liu, Ziyue</creatorcontrib><creatorcontrib>Case, Jamie</creatorcontrib><creatorcontrib>Ingram, David A.</creatorcontrib><creatorcontrib>Gupta, Samir K.</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hays, Travis R.</au><au>Mund, Julie A.</au><au>Liu, Ziyue</au><au>Case, Jamie</au><au>Ingram, David A.</au><au>Gupta, Samir K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><date>2015-04-15</date><risdate>2015</risdate><volume>68</volume><issue>5</issue><spage>550</spage><epage>553</epage><pages>550-553</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><abstract>The relationships between HIV infection, monocyte activation, and endothelial colony forming cells (ECFCs) are unknown. We compared ECFC, intermediate monocytes (CD14
+
CD16
+
), and non-classical monocytes (CD14
dim
CD16
++
) levels in HIV-infected participants virologically-suppressed on antiretroviral therapy, HIV-infected treatment-naïve participants, and HIV-uninfected healthy controls. ECFC levels were significantly higher in the HIV-infected, virologically-suppressed group compared to the uninfected controls. CD14
+
CD16
+
percentages (but not CD14
dim
CD16
++
cells) were significantly higher in both HIV-infected groups vs uninfected controls. In the HIV-infected groups, ECFCs and CD14
+
CD16
+
intermediate monocytes were significantly and inversely correlated. Lower availability of ECFCs may partly explain the relationship between greater intermediate monocytes and atherosclerosis in HIV.</abstract><pmid>25564108</pmid><doi>10.1097/QAI.0000000000000506</doi><tpages>4</tpages></addata></record> |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4357537 |
| source | Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
| title | Endothelial Colony Forming Cells and Inflammatory Monocytes in HIV |
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