Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study
Abstract Objectives To investigate the relationship between area deprivation, individual socio-economic status (SES) and age related macular degeneration (AMD). Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by...
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| Veröffentlicht in: | Public health (London) 2015-02, Vol.129 (2), p.103-109 |
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| creator | Yip, Jennifer L.Y Khawaja, Anthony P Chan, Michelle P.Y Broadway, David C Peto, Tunde Luben, Robert Hayat, Shabina Bhaniani, Amit Wareham, Nick Foster, Paul J Khaw, Kay-Tee |
| description | Abstract Objectives To investigate the relationship between area deprivation, individual socio-economic status (SES) and age related macular degeneration (AMD). Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by trained nurses, using standardized protocols and lifestyle questionnaires. The English Index of multiple deprivation 2010 (IMD) was derived from participants' postcodes. AMD was identified from standardized grading of fundus photographs. Logistic regression was used to examine associations between IMD, SES and AMD. Results 5344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD. Of 5182 participants with complete data, AMD was identified in 653 participants (12.60%, 95%CI = 11.7–13.5%). Multivariable logistic regression showed that people living in the most affluent 5% of areas had nearly half the odds of AMD compared to those living in comparatively more deprived areas (OR = 0.56, 95% CI = 0.36–0.89, P = 0.02), after adjusting for age, sex, education, social class and smoking. Conclusions The authors found that living in the most affluent areas exerted a protective effect on AMD, independently of education and social class. Further investigation into underlying mechanisms will inform potential interventions to reduce health inequalities relating to AMD. |
| doi_str_mv | 10.1016/j.puhe.2014.10.012 |
| format | Article |
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Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by trained nurses, using standardized protocols and lifestyle questionnaires. The English Index of multiple deprivation 2010 (IMD) was derived from participants' postcodes. AMD was identified from standardized grading of fundus photographs. Logistic regression was used to examine associations between IMD, SES and AMD. Results 5344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD. Of 5182 participants with complete data, AMD was identified in 653 participants (12.60%, 95%CI = 11.7–13.5%). Multivariable logistic regression showed that people living in the most affluent 5% of areas had nearly half the odds of AMD compared to those living in comparatively more deprived areas (OR = 0.56, 95% CI = 0.36–0.89, P = 0.02), after adjusting for age, sex, education, social class and smoking. Conclusions The authors found that living in the most affluent areas exerted a protective effect on AMD, independently of education and social class. Further investigation into underlying mechanisms will inform potential interventions to reduce health inequalities relating to AMD.</description><identifier>ISSN: 0033-3506</identifier><identifier>EISSN: 1476-5616</identifier><identifier>DOI: 10.1016/j.puhe.2014.10.012</identifier><identifier>PMID: 25687711</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Area deprivation ; Cross-Sectional Studies ; Female ; Health Status Disparities ; Humans ; Inequalities ; Infectious Disease ; Internal Medicine ; Life Style ; Logistic Models ; Macular degeneration ; Macular Degeneration - epidemiology ; Male ; Middle Aged ; Multivariate Analysis ; Original Research ; Poverty Areas ; Risk Factors ; Smoking - epidemiology ; Social Class ; Surveys and Questionnaires ; United Kingdom - epidemiology</subject><ispartof>Public health (London), 2015-02, Vol.129 (2), p.103-109</ispartof><rights>The Authors</rights><rights>2014 The Authors</rights><rights>Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><rights>2014 The Authors 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c662t-1b108e06aa84847c02ce1d85c0717bb7c1c96a63c4825e32c55b350785c8025f3</citedby><cites>FETCH-LOGICAL-c662t-1b108e06aa84847c02ce1d85c0717bb7c1c96a63c4825e32c55b350785c8025f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.puhe.2014.10.012$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25687711$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yip, Jennifer L.Y</creatorcontrib><creatorcontrib>Khawaja, Anthony P</creatorcontrib><creatorcontrib>Chan, Michelle P.Y</creatorcontrib><creatorcontrib>Broadway, David C</creatorcontrib><creatorcontrib>Peto, Tunde</creatorcontrib><creatorcontrib>Luben, Robert</creatorcontrib><creatorcontrib>Hayat, Shabina</creatorcontrib><creatorcontrib>Bhaniani, Amit</creatorcontrib><creatorcontrib>Wareham, Nick</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><creatorcontrib>Khaw, Kay-Tee</creatorcontrib><title>Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study</title><title>Public health (London)</title><addtitle>Public Health</addtitle><description>Abstract Objectives To investigate the relationship between area deprivation, individual socio-economic status (SES) and age related macular degeneration (AMD). Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by trained nurses, using standardized protocols and lifestyle questionnaires. The English Index of multiple deprivation 2010 (IMD) was derived from participants' postcodes. AMD was identified from standardized grading of fundus photographs. Logistic regression was used to examine associations between IMD, SES and AMD. Results 5344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD. Of 5182 participants with complete data, AMD was identified in 653 participants (12.60%, 95%CI = 11.7–13.5%). Multivariable logistic regression showed that people living in the most affluent 5% of areas had nearly half the odds of AMD compared to those living in comparatively more deprived areas (OR = 0.56, 95% CI = 0.36–0.89, P = 0.02), after adjusting for age, sex, education, social class and smoking. Conclusions The authors found that living in the most affluent areas exerted a protective effect on AMD, independently of education and social class. Further investigation into underlying mechanisms will inform potential interventions to reduce health inequalities relating to AMD.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Area deprivation</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Health Status Disparities</subject><subject>Humans</subject><subject>Inequalities</subject><subject>Infectious Disease</subject><subject>Internal Medicine</subject><subject>Life Style</subject><subject>Logistic Models</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Original Research</subject><subject>Poverty Areas</subject><subject>Risk Factors</subject><subject>Smoking - epidemiology</subject><subject>Social Class</subject><subject>Surveys and Questionnaires</subject><subject>United Kingdom - epidemiology</subject><issn>0033-3506</issn><issn>1476-5616</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9rGzEQxUVpaFy3X6CHssde1tVo9WcNJRCM2wZCWnB7Flrt2Jazllxp1-BvXy1OQ5tD6EEIRr95aOY9Qt4BnQEF-XE3OwxbnDEKPBdmFNgLMgGuZCkkyJdkQmlVlZWg8pK8TmlHKWWqEq_IJROyVgpgQlbXEU3R4iG6o-ld8IXxbWE2WETsTI9tsTd26EzMzAY9xjPkfNFvsVh-v1mUdyGuQ3dfLE9YrPqhPb0hF2vTJXz7cE_Jz8_LH4uv5e23LzeL69vSSsn6EhqgNVJpTM1rrixlFqGthaUKVNMoC3Yujawsr5nAilkhmjyMykRNmVhXU3J11j0MzR5bi76PptN5lL2JJx2M0_--eLfVm3DUvBIqnyzw4UEghl8Dpl7vXbLYdcZjGJIGWVPOGRXyP1AJ83oOeeVTws6ojSGliOvHHwHVo3F6p0fj9GjcWMvG5ab3f8_y2PLHqQx8OgOYN3p0GHWyDr3F1kW0vW6De17_6km77Zx31nT3eMK0C0P02SsNOjFN9WqMzpgc4GNoOFS_AT9fvZw</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>Yip, Jennifer L.Y</creator><creator>Khawaja, Anthony P</creator><creator>Chan, Michelle P.Y</creator><creator>Broadway, David C</creator><creator>Peto, Tunde</creator><creator>Luben, Robert</creator><creator>Hayat, Shabina</creator><creator>Bhaniani, Amit</creator><creator>Wareham, Nick</creator><creator>Foster, Paul J</creator><creator>Khaw, Kay-Tee</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>5PM</scope></search><sort><creationdate>20150201</creationdate><title>Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study</title><author>Yip, Jennifer L.Y ; Khawaja, Anthony P ; Chan, Michelle P.Y ; Broadway, David C ; Peto, Tunde ; Luben, Robert ; Hayat, Shabina ; Bhaniani, Amit ; Wareham, Nick ; Foster, Paul J ; Khaw, Kay-Tee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c662t-1b108e06aa84847c02ce1d85c0717bb7c1c96a63c4825e32c55b350785c8025f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Area deprivation</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Health Status Disparities</topic><topic>Humans</topic><topic>Inequalities</topic><topic>Infectious Disease</topic><topic>Internal Medicine</topic><topic>Life Style</topic><topic>Logistic Models</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Original Research</topic><topic>Poverty Areas</topic><topic>Risk Factors</topic><topic>Smoking - epidemiology</topic><topic>Social Class</topic><topic>Surveys and Questionnaires</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yip, Jennifer L.Y</creatorcontrib><creatorcontrib>Khawaja, Anthony P</creatorcontrib><creatorcontrib>Chan, Michelle P.Y</creatorcontrib><creatorcontrib>Broadway, David C</creatorcontrib><creatorcontrib>Peto, Tunde</creatorcontrib><creatorcontrib>Luben, Robert</creatorcontrib><creatorcontrib>Hayat, Shabina</creatorcontrib><creatorcontrib>Bhaniani, Amit</creatorcontrib><creatorcontrib>Wareham, Nick</creatorcontrib><creatorcontrib>Foster, Paul J</creatorcontrib><creatorcontrib>Khaw, Kay-Tee</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Public health (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yip, Jennifer L.Y</au><au>Khawaja, Anthony P</au><au>Chan, Michelle P.Y</au><au>Broadway, David C</au><au>Peto, Tunde</au><au>Luben, Robert</au><au>Hayat, Shabina</au><au>Bhaniani, Amit</au><au>Wareham, Nick</au><au>Foster, Paul J</au><au>Khaw, Kay-Tee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study</atitle><jtitle>Public health (London)</jtitle><addtitle>Public Health</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>129</volume><issue>2</issue><spage>103</spage><epage>109</epage><pages>103-109</pages><issn>0033-3506</issn><eissn>1476-5616</eissn><abstract>Abstract Objectives To investigate the relationship between area deprivation, individual socio-economic status (SES) and age related macular degeneration (AMD). Study design Cross sectional study nested within a longitudinal cohort study. Methods Data were collected in the EPIC-Norfolk Eye Study by trained nurses, using standardized protocols and lifestyle questionnaires. The English Index of multiple deprivation 2010 (IMD) was derived from participants' postcodes. AMD was identified from standardized grading of fundus photographs. Logistic regression was used to examine associations between IMD, SES and AMD. Results 5344 pairs (62.0% of total 8623) of fundus photographs were of sufficient quality for grading of AMD. Of 5182 participants with complete data, AMD was identified in 653 participants (12.60%, 95%CI = 11.7–13.5%). Multivariable logistic regression showed that people living in the most affluent 5% of areas had nearly half the odds of AMD compared to those living in comparatively more deprived areas (OR = 0.56, 95% CI = 0.36–0.89, P = 0.02), after adjusting for age, sex, education, social class and smoking. Conclusions The authors found that living in the most affluent areas exerted a protective effect on AMD, independently of education and social class. Further investigation into underlying mechanisms will inform potential interventions to reduce health inequalities relating to AMD.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>25687711</pmid><doi>10.1016/j.puhe.2014.10.012</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Area deprivation Cross-Sectional Studies Female Health Status Disparities Humans Inequalities Infectious Disease Internal Medicine Life Style Logistic Models Macular degeneration Macular Degeneration - epidemiology Male Middle Aged Multivariate Analysis Original Research Poverty Areas Risk Factors Smoking - epidemiology Social Class Surveys and Questionnaires United Kingdom - epidemiology |
| title | Area deprivation and age related macular degeneration in the EPIC-Norfolk Eye Study |
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