Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-Inducing Chemotherapies

Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5. Paclitaxel-induced ER stress to breast cancer (BCa) cells promotes RNF5 association, u...

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Veröffentlicht in:	Cancer cell 2015-03, Vol.27 (3), p.354-369
Hauptverfasser:	Jeon, Young Joo, Khelifa, Sihem, Ratnikov, Boris, Scott, David A., Feng, Yongmei, Parisi, Fabio, Ruller, Chelsea, Lau, Eric, Kim, Hyungsoo, Brill, Laurence M., Jiang, Tingting, Rimm, David L., Cardiff, Robert D., Mills, Gordon B., Smith, Jeffrey W., Osterman, Andrei L., Kluger, Yuval, Ronai, Ze’ev A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System A - genetics Amino Acid Transport System A - metabolism Amino Acid Transport System ASC - genetics Amino Acid Transport System ASC - metabolism Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Apoptosis - drug effects Autophagy - drug effects Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Citric Acid Cycle - drug effects DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Endoplasmic Reticulum - drug effects Endoplasmic Reticulum Stress - drug effects Endoplasmic Reticulum Stress - genetics Female Humans Mice, Inbred BALB C Mice, Inbred C57BL Mice, Nude Minor Histocompatibility Antigens Paclitaxel - pharmacology Paclitaxel - therapeutic use Proteolysis - drug effects Signal Transduction - drug effects TOR Serine-Threonine Kinases - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitin-Protein Ligases - physiology Ubiquitination
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