Neutralization of staphylococcal enterotoxin B by an aptamer antagonist

Staphylococcal enterotoxin B (SEB) is a major virulence factor for staphylococcal toxic shock syndrome (TSS). SEB activates a large subset of the T lymphocytic population, releasing proinflammatory cytokines. Blocking SEB-initiated toxicity may be an effective strategy for treating TSS. Using a proc...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2015-04, Vol.59 (4), p.2072-2077
Hauptverfasser:	Wang, Kaiyu, Gan, Longjie, Jiang, Li, Zhang, Xianhui, Yang, Xiangyue, Chen, Min, Lan, Xiaopeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation - drug effects Cloning, Molecular Computational Biology Cytokines - biosynthesis Drug Evaluation, Preclinical Enterotoxins Enterotoxins - antagonists & inhibitors Experimental Therapeutics Female Galactosamine - pharmacology Humans Mice Mice, Inbred BALB C Monocytes - drug effects SELEX Aptamer Technique Shock, Septic - drug therapy Shock, Septic - microbiology
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