The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

Background and Objectives: The gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) acutely suppress appetite. The short chain fatty acid (SCFA) receptor, free fatty acid receptor 2 (FFA2) is present on colonic enteroendocrine L cells, and a role has been suggested for SCFAs in appetite...

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Veröffentlicht in:	International Journal of Obesity 2015-03, Vol.39 (3), p.424-429
Hauptverfasser:	Psichas, A, Sleeth, M L, Murphy, K G, Brooks, L, Bewick, G A, Hanyaloglu, A C, Ghatei, M A, Bloom, S R, Frost, G
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 631/443/163 631/443/319 631/45/287/1183 631/45/776/198 631/80/86 64 64/110 Animals Appetite Biological control systems Colon - metabolism Colon - pathology Diabetes Diet Endocrinology Epidemiology Fatty acids Gastrointestinal hormones Gastrointestinal Hormones - metabolism Glucagon Glucagon-Like Peptide 1 - drug effects Glucagon-Like Peptide 1 - metabolism Glucose Health Promotion and Disease Prevention Hormones Internal Medicine Measurement Medical research Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice Mice, Inbred C57BL Microbiota Nutrients Nutrition research Obesity Original original-article Peptide YY - metabolism Peptides Physiological research Properties Propionates - pharmacology Public Health Rats Rats, Wistar Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism Rodents Small intestine Weight control
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