Structures of the human Pals1 PDZ domain with and without ligand suggest gated access of Crb to the PDZ peptide-binding groove

Many components of epithelial polarity protein complexes possess PDZ domains that are required for protein interaction and recruitment to the apical plasma membrane. Apical localization of the Crumbs (Crb) transmembrane protein requires a PDZ‐mediated interaction with Pals1 (protein‐associated with...

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Veröffentlicht in:	Acta crystallographica. Section D, Biological crystallography. Biological crystallography., 2015-03, Vol.71 (3), p.555-564
Hauptverfasser:	Ivanova, Marina E., Fletcher, Georgina C., O'Reilly, Nicola, Purkiss, Andrew G., Thompson, Barry J., McDonald, Neil Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	AFFINITY Amino Acid Motifs Animals Binding cell polarity Chains CHROMIUM BORIDES CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND SUPERFLUIDITY Crb CRYSTALLOGRAPHY CRYSTALS Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism epithelia Eye Proteins - chemistry Eye Proteins - genetics Eye Proteins - metabolism FLUORESCENCE Grooves Guanylate Kinases - chemistry Guanylate Kinases - genetics Guanylate Kinases - metabolism Humans INTERACTIONS Kinases LIGANDS Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Transport Proteins - chemistry Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism MEMBRANES Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nucleoside-Phosphate Kinase - chemistry Nucleoside-Phosphate Kinase - genetics Nucleoside-Phosphate Kinase - metabolism PDZ domains PLASMA Polarity POLARIZATION Protein Binding Protein Structure, Quaternary Protein Structure, Tertiary Proteins Research Papers SPECIFICITY stardust
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