Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations
Abstract Background and aims Lipoprotein lipase ( LPL ) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. Methods and results We exa...
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| Veröffentlicht in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2014-12, Vol.24 (12), p.1323-1329 |
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| creator | Ma, Y Tucker, K.L Smith, C.E Lee, Y.C Huang, T Richardson, K Parnell, L.D Lai, C.Q Young, K.L Justice, A.E Shao, Y North, K.E Ordovás, J.M |
| description | Abstract Background and aims Lipoprotein lipase ( LPL ) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. Methods and results We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45–75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) ( P = 0.002) and waist circumference (WC) ( P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) ( P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study ( n = 1334). Conclusion Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women. |
| doi_str_mv | 10.1016/j.numecd.2014.07.003 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4356006</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0939475314002312</els_id><sourcerecordid>2101319253</sourcerecordid><originalsourceid>FETCH-LOGICAL-c621t-1b2f4821160bf815a65d90b3ba5adc285b5f668f060b173ee48175ab7956cc4b3</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhiMEotvCP0DIRy4J_k7CAQlVQJFWQuLjbDnOhHpJ7GA7u9oj_xynW8rHpSdLM--8nplniuIZwRXBRL7cVW6ZwPQVxYRXuK4wZg-KDREtLllN24fFBresLXkt2FlxHuMuC2rM-OPijAoiZNPyTfFza2c_B5_AOjTaWUdAex2sdiki6xIEbRI62HSNZj8eFxd1WoJO0KNBp3RE2tg-osEH5DuINkdS0PamGB38BO4V-gTzaI1O1rs1mg4-e83LeBOJT4pHgx4jPL19L4qv795-ubwqtx_ff7h8sy2NpCSVpKMDbyghEndDQ4SWom9xxzotdG9oIzoxSNkMOOdJzQB4Q2qhu7oV0hjesYvi9cl3XroJegMuNzqqOdhJh6Py2qp_M85eq29-rzgTEmOZDV7cGgT_Y4GY1GSjgXHUDvwSFc1YGGmpYPdKiaStaGpS8yzlJ6kJPsYAw11HBKsVtNqpE2i1gla4VpljLnv-9zR3Rb_J_hkX8k73FoKKxoIz0NsAJqne2_t--N_AjNZljuN3OELc-SW4zEsRFanC6vN6bOutEY4xZYSyX5RC1Ig</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629587174</pqid></control><display><type>article</type><title>Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ma, Y ; Tucker, K.L ; Smith, C.E ; Lee, Y.C ; Huang, T ; Richardson, K ; Parnell, L.D ; Lai, C.Q ; Young, K.L ; Justice, A.E ; Shao, Y ; North, K.E ; Ordovás, J.M</creator><creatorcontrib>Ma, Y ; Tucker, K.L ; Smith, C.E ; Lee, Y.C ; Huang, T ; Richardson, K ; Parnell, L.D ; Lai, C.Q ; Young, K.L ; Justice, A.E ; Shao, Y ; North, K.E ; Ordovás, J.M</creatorcontrib><description>Abstract Background and aims Lipoprotein lipase ( LPL ) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. Methods and results We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45–75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) ( P = 0.002) and waist circumference (WC) ( P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) ( P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study ( n = 1334). Conclusion Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.</description><identifier>ISSN: 0939-4753</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2014.07.003</identifier><identifier>PMID: 25156894</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>African Americans ; Aged ; Aged, 80 and over ; alleles ; atherosclerosis ; Atherosclerosis - epidemiology ; Body Mass Index ; Boston ; Cardiovascular ; Diet ; dietary fat ; European Continental Ancestry Group ; Fatty Acids, Unsaturated - blood ; Feeding Behavior ; Female ; Gene-diet interaction ; Hispanic Americans ; homozygosity ; Humans ; hydrolysis ; Indians, North American ; Linkage Disequilibrium ; Lipoprotein lipase ; Lipoprotein Lipase - genetics ; Lipoprotein Lipase - metabolism ; Male ; men ; metabolism ; Middle Aged ; Obesity ; Obesity - enzymology ; Obesity - epidemiology ; Obesity - genetics ; oxidation ; Polymorphism, Single Nucleotide - genetics ; Polyunsaturated fatty acids ; risk ; single nucleotide polymorphism ; triacylglycerols ; waist circumference ; women</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2014-12, Vol.24 (12), p.1323-1329</ispartof><rights>2014</rights><rights>Copyright © 2014. Published by Elsevier B.V.</rights><rights>2014 Published by Elsevier B.V. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-1b2f4821160bf815a65d90b3ba5adc285b5f668f060b173ee48175ab7956cc4b3</citedby><cites>FETCH-LOGICAL-c621t-1b2f4821160bf815a65d90b3ba5adc285b5f668f060b173ee48175ab7956cc4b3</cites><orcidid>0000-0002-7581-5680 ; 0000-0002-7711-0457 ; 0000-0002-9511-1103 ; 0000-0002-3609-8877</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.numecd.2014.07.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25156894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ma, Y</creatorcontrib><creatorcontrib>Tucker, K.L</creatorcontrib><creatorcontrib>Smith, C.E</creatorcontrib><creatorcontrib>Lee, Y.C</creatorcontrib><creatorcontrib>Huang, T</creatorcontrib><creatorcontrib>Richardson, K</creatorcontrib><creatorcontrib>Parnell, L.D</creatorcontrib><creatorcontrib>Lai, C.Q</creatorcontrib><creatorcontrib>Young, K.L</creatorcontrib><creatorcontrib>Justice, A.E</creatorcontrib><creatorcontrib>Shao, Y</creatorcontrib><creatorcontrib>North, K.E</creatorcontrib><creatorcontrib>Ordovás, J.M</creatorcontrib><title>Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Abstract Background and aims Lipoprotein lipase ( LPL ) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. Methods and results We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45–75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) ( P = 0.002) and waist circumference (WC) ( P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) ( P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study ( n = 1334). Conclusion Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.</description><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>alleles</subject><subject>atherosclerosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Body Mass Index</subject><subject>Boston</subject><subject>Cardiovascular</subject><subject>Diet</subject><subject>dietary fat</subject><subject>European Continental Ancestry Group</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Feeding Behavior</subject><subject>Female</subject><subject>Gene-diet interaction</subject><subject>Hispanic Americans</subject><subject>homozygosity</subject><subject>Humans</subject><subject>hydrolysis</subject><subject>Indians, North American</subject><subject>Linkage Disequilibrium</subject><subject>Lipoprotein lipase</subject><subject>Lipoprotein Lipase - genetics</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>men</subject><subject>metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - enzymology</subject><subject>Obesity - epidemiology</subject><subject>Obesity - genetics</subject><subject>oxidation</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Polyunsaturated fatty acids</subject><subject>risk</subject><subject>single nucleotide polymorphism</subject><subject>triacylglycerols</subject><subject>waist circumference</subject><subject>women</subject><issn>0939-4753</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEotvCP0DIRy4J_k7CAQlVQJFWQuLjbDnOhHpJ7GA7u9oj_xynW8rHpSdLM--8nplniuIZwRXBRL7cVW6ZwPQVxYRXuK4wZg-KDREtLllN24fFBresLXkt2FlxHuMuC2rM-OPijAoiZNPyTfFza2c_B5_AOjTaWUdAex2sdiki6xIEbRI62HSNZj8eFxd1WoJO0KNBp3RE2tg-osEH5DuINkdS0PamGB38BO4V-gTzaI1O1rs1mg4-e83LeBOJT4pHgx4jPL19L4qv795-ubwqtx_ff7h8sy2NpCSVpKMDbyghEndDQ4SWom9xxzotdG9oIzoxSNkMOOdJzQB4Q2qhu7oV0hjesYvi9cl3XroJegMuNzqqOdhJh6Py2qp_M85eq29-rzgTEmOZDV7cGgT_Y4GY1GSjgXHUDvwSFc1YGGmpYPdKiaStaGpS8yzlJ6kJPsYAw11HBKsVtNqpE2i1gla4VpljLnv-9zR3Rb_J_hkX8k73FoKKxoIz0NsAJqne2_t--N_AjNZljuN3OELc-SW4zEsRFanC6vN6bOutEY4xZYSyX5RC1Ig</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Ma, Y</creator><creator>Tucker, K.L</creator><creator>Smith, C.E</creator><creator>Lee, Y.C</creator><creator>Huang, T</creator><creator>Richardson, K</creator><creator>Parnell, L.D</creator><creator>Lai, C.Q</creator><creator>Young, K.L</creator><creator>Justice, A.E</creator><creator>Shao, Y</creator><creator>North, K.E</creator><creator>Ordovás, J.M</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7581-5680</orcidid><orcidid>https://orcid.org/0000-0002-7711-0457</orcidid><orcidid>https://orcid.org/0000-0002-9511-1103</orcidid><orcidid>https://orcid.org/0000-0002-3609-8877</orcidid></search><sort><creationdate>20141201</creationdate><title>Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations</title><author>Ma, Y ; Tucker, K.L ; Smith, C.E ; Lee, Y.C ; Huang, T ; Richardson, K ; Parnell, L.D ; Lai, C.Q ; Young, K.L ; Justice, A.E ; Shao, Y ; North, K.E ; Ordovás, J.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-1b2f4821160bf815a65d90b3ba5adc285b5f668f060b173ee48175ab7956cc4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>alleles</topic><topic>atherosclerosis</topic><topic>Atherosclerosis - epidemiology</topic><topic>Body Mass Index</topic><topic>Boston</topic><topic>Cardiovascular</topic><topic>Diet</topic><topic>dietary fat</topic><topic>European Continental Ancestry Group</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Feeding Behavior</topic><topic>Female</topic><topic>Gene-diet interaction</topic><topic>Hispanic Americans</topic><topic>homozygosity</topic><topic>Humans</topic><topic>hydrolysis</topic><topic>Indians, North American</topic><topic>Linkage Disequilibrium</topic><topic>Lipoprotein lipase</topic><topic>Lipoprotein Lipase - genetics</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>men</topic><topic>metabolism</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - enzymology</topic><topic>Obesity - epidemiology</topic><topic>Obesity - genetics</topic><topic>oxidation</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Polyunsaturated fatty acids</topic><topic>risk</topic><topic>single nucleotide polymorphism</topic><topic>triacylglycerols</topic><topic>waist circumference</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Y</creatorcontrib><creatorcontrib>Tucker, K.L</creatorcontrib><creatorcontrib>Smith, C.E</creatorcontrib><creatorcontrib>Lee, Y.C</creatorcontrib><creatorcontrib>Huang, T</creatorcontrib><creatorcontrib>Richardson, K</creatorcontrib><creatorcontrib>Parnell, L.D</creatorcontrib><creatorcontrib>Lai, C.Q</creatorcontrib><creatorcontrib>Young, K.L</creatorcontrib><creatorcontrib>Justice, A.E</creatorcontrib><creatorcontrib>Shao, Y</creatorcontrib><creatorcontrib>North, K.E</creatorcontrib><creatorcontrib>Ordovás, J.M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Y</au><au>Tucker, K.L</au><au>Smith, C.E</au><au>Lee, Y.C</au><au>Huang, T</au><au>Richardson, K</au><au>Parnell, L.D</au><au>Lai, C.Q</au><au>Young, K.L</au><au>Justice, A.E</au><au>Shao, Y</au><au>North, K.E</au><au>Ordovás, J.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>24</volume><issue>12</issue><spage>1323</spage><epage>1329</epage><pages>1323-1329</pages><issn>0939-4753</issn><eissn>1590-3729</eissn><abstract>Abstract Background and aims Lipoprotein lipase ( LPL ) is a candidate gene for obesity based on its role in triglyceride hydrolysis and the partitioning of fatty acids towards storage or oxidation. Whether dietary fatty acids modify LPL associated obesity risk is unknown. Methods and results We examined five single nucleotide polymorphisms (SNPs) (rs320, rs2083637, rs17411031, rs13702, rs2197089) for potential interaction with dietary fatty acids for obesity traits in 1171 participants (333 men and 838 women, aged 45–75 y) of the Boston Puerto Rican Health Study (BPRHS). In women, SNP rs320 interacted with dietary polyunsaturated fatty acids (PUFA) for body mass index (BMI) ( P = 0.002) and waist circumference (WC) ( P = 0.001) respectively. Higher intake of PUFA was associated with lower BMI and WC in homozygotes of the major allele (TT) ( P = 0.01 and 0.005) but not in minor allele carriers (TG and GG). These interactions were replicated in an independent population, African American women of the Atherosclerosis Risk in Communities (ARIC) study ( n = 1334). Conclusion Dietary PUFA modulated the association of LPL rs320 with obesity traits in two independent populations. These interactions may be relevant to the dietary management of obesity, particularly in women.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25156894</pmid><doi>10.1016/j.numecd.2014.07.003</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7581-5680</orcidid><orcidid>https://orcid.org/0000-0002-7711-0457</orcidid><orcidid>https://orcid.org/0000-0002-9511-1103</orcidid><orcidid>https://orcid.org/0000-0002-3609-8877</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | African Americans Aged Aged, 80 and over alleles atherosclerosis Atherosclerosis - epidemiology Body Mass Index Boston Cardiovascular Diet dietary fat European Continental Ancestry Group Fatty Acids, Unsaturated - blood Feeding Behavior Female Gene-diet interaction Hispanic Americans homozygosity Humans hydrolysis Indians, North American Linkage Disequilibrium Lipoprotein lipase Lipoprotein Lipase - genetics Lipoprotein Lipase - metabolism Male men metabolism Middle Aged Obesity Obesity - enzymology Obesity - epidemiology Obesity - genetics oxidation Polymorphism, Single Nucleotide - genetics Polyunsaturated fatty acids risk single nucleotide polymorphism triacylglycerols waist circumference women |
| title | Lipoprotein lipase variants interact with polyunsaturated fatty acids for obesity traits in women: Replication in two populations |
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