The effect of silibinin in enhancing toxicity of temozolomide and etoposide in p53 and PTEN-mutated resistant glioma cell lines

Glioblastoma multiforme (GBM) is an intractable brain tumor, associated with poor prognosis and low survival rate. Combination therapy such as surgery, radiotherapy and temozolomide is considered standard in overcoming this aggressive cancer, despite poor prognosis. There is a need to identify poten...

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Veröffentlicht in:	Anticancer research 2015-03, Vol.35 (3), p.1263-1269
Hauptverfasser:	Elhag, Rashid, Mazzio, Elizabeth A, Soliman, Karam F A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Brain Neoplasms - drug therapy Brain Neoplasms - pathology Cell Line, Tumor Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Drug Resistance, Neoplasm Drug Synergism Etoposide - pharmacology Genes, p53 Glioma - drug therapy Glioma - pathology Humans Inhibitor of Apoptosis Proteins - analysis Inhibitor of Apoptosis Proteins - physiology Mutation PTEN Phosphohydrolase - genetics Silymarin - pharmacology
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