Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury

We had previously shown that alcohol consumption can induce cellular isoaspartate protein damage via an impairment of the activity of protein isoaspartyl methyltransferase (PIMT), an enzyme that triggers repair of isoaspartate protein damage. To further investigate the mechanism of isoaspartate accu...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-03, Vol.458 (3), p.626-631
Hauptverfasser:	Carter, Wayne G, Vigneswara, Vasanthy, Newlaczyl, Anna, Wayne, Declan, Ahmed, Bilal, Saddington, Stephen, Brewer, Charlotte, Raut, Nikhilesh, Gerdes, Henry K, Erdozain, Amaia M, Tooth, David, Bolt, Edward L, Osna, Natalie A, Tuma, Dean J, Kharbanda, Kusum K
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine alcohol drinking Animals autoradiography betaine biomarkers Biomarkers - analysis Biomarkers - metabolism Carbamoyl-Phosphate Synthase (Ammonia) - analysis Carbamoyl-Phosphate Synthase (Ammonia) - metabolism Carbonic Anhydrase III - analysis Carbonic Anhydrase III - metabolism Cells, Cultured Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - genetics Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology chromatography ethanol Ethanol - adverse effects gel electrophoresis hepatocytes homocysteine Isoaspartic Acid - analysis Isoaspartic Acid - metabolism liver Liver - drug effects Liver - metabolism Liver - pathology Male methyltransferases Mice Mice, Knockout phosphates Protein D-Aspartate-L-Isoaspartate Methyltransferase - genetics Protein D-Aspartate-L-Isoaspartate Methyltransferase - metabolism proteins proteome Rats Rats, Wistar S-Adenosylhomocysteine - metabolism
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