After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance
Abstract Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintain...
Gespeichert in:
| Veröffentlicht in: | Physiology & behavior 2008-06, Vol.94 (3), p.309-315 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 315 |
|---|---|
| container_issue | 3 |
| container_start_page | 309 |
| container_title | Physiology & behavior |
| container_volume | 94 |
| creator | Avena, Nicole M Bocarsly, Miriam E Rada, Pedro Kim, Agnes Hoebel, Bartley G |
| description | Abstract Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintained on 12-h deprivation followed by 12-h access to a 10% sucrose solution and chow for 28 days, then fasted for 36 h. These animals spent less time on the exposed arm of an elevated plus-maze compared with a similarly deprived ad libitum chow group, suggesting anxiety. Microdialysis revealed a concomitant increase in extracellular acetylcholine and decrease in dopamine release in the nucleus accumbens shell. These results did not appear to be due to hypoglycemia. The findings suggest that a diet of bingeing on sucrose and chow followed by fasting creates a state that involves anxiety and altered accumbens dopamine and acetylcholine balance. This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders. |
| doi_str_mv | 10.1016/j.physbeh.2008.01.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4354893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0031938408000103</els_id><sourcerecordid>70764233</sourcerecordid><originalsourceid>FETCH-LOGICAL-c581t-f4660dddf198e527a38cea25ef3cbfa91976e343199d025907ac7f1ae0408bf43</originalsourceid><addsrcrecordid>eNqFUk1v1DAQjRCIbgs_AeQLnLpbO3YS59KqqviSKnEAJG6WY4-7XhJ7sZMVK_48E3ZVPi61ZI1sv3meN2-K4gWjK0ZZfbFZbdf73MF6VVIqV5StMDwqFkw2fFnR5uvjYkEpZ8uWS3FSnOa8obi44E-LEyZ5WVWiXhQ_r90IiVjt-z3pfLgD3CQGokmeTIoZSI79NPoYzomL0RIL2-R3er4hPtjJQCY6_PAw7jFaoo2Zhg5CJjZu9eADXGiDj71Zxx5PxA-d7nUw8Kx44nSf4fkxnhVf3r75fPN-efvx3Yeb69ulqSQbl07UNbXWOtZKqMpGc2lAlxU4bjqnW9Y2NaAu1raWllVLG20axzRQQWXnBD8rLg-826kbwBoIY9K9QhmDTnsVtVf_vgS_VndxpwSvhGw5Erw-EqT4fYI8qsFnAz2qgDhl1dCmFiV_GMjQjFqyGoHVATi3OCdw99UwqmZ_1UYd_VWzv4oyhQHzXv4t5U_W0VAEvDoCdDa6dwkb7fM9rqSiEuy3pKsDDrDxOw9JZeMBTbE-gRmVjf7BUi7_YzBor8dPv8Ee8iZOKaCriqlcKqo-zcM4zyKVOIaMcv4L0ZbfNw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>19386816</pqid></control><display><type>article</type><title>After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Avena, Nicole M ; Bocarsly, Miriam E ; Rada, Pedro ; Kim, Agnes ; Hoebel, Bartley G</creator><creatorcontrib>Avena, Nicole M ; Bocarsly, Miriam E ; Rada, Pedro ; Kim, Agnes ; Hoebel, Bartley G</creatorcontrib><description>Abstract Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintained on 12-h deprivation followed by 12-h access to a 10% sucrose solution and chow for 28 days, then fasted for 36 h. These animals spent less time on the exposed arm of an elevated plus-maze compared with a similarly deprived ad libitum chow group, suggesting anxiety. Microdialysis revealed a concomitant increase in extracellular acetylcholine and decrease in dopamine release in the nucleus accumbens shell. These results did not appear to be due to hypoglycemia. The findings suggest that a diet of bingeing on sucrose and chow followed by fasting creates a state that involves anxiety and altered accumbens dopamine and acetylcholine balance. This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/j.physbeh.2008.01.008</identifier><identifier>PMID: 18325546</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Acetylcholine ; Acetylcholine - metabolism ; Adult and adolescent clinical studies ; Analysis of Variance ; Animals ; Anxiety - etiology ; Behavior, Animal ; Behavioral psychophysiology ; Binge eating ; Bingeing ; Biological and medical sciences ; Blood Glucose ; Bulimia - complications ; Dopamine ; Dopamine - metabolism ; Eating - physiology ; Eating behavior disorders ; Energy Intake - physiology ; Feeding Behavior - physiology ; Feeding Behavior - psychology ; Food Deprivation ; Fundamental and applied biological sciences. Psychology ; Male ; Medical sciences ; Microdialysis ; Miscellaneous ; Nucleus accumbens ; Nucleus Accumbens - metabolism ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Psychopathology. Psychiatry ; Rats ; Rats, Sprague-Dawley ; Sucrose</subject><ispartof>Physiology & behavior, 2008-06, Vol.94 (3), p.309-315</ispartof><rights>Elsevier Inc.</rights><rights>2008 Elsevier Inc.</rights><rights>2008 INIST-CNRS</rights><rights>2008 Elsevier Inc. All rights reserved. 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-f4660dddf198e527a38cea25ef3cbfa91976e343199d025907ac7f1ae0408bf43</citedby><cites>FETCH-LOGICAL-c581t-f4660dddf198e527a38cea25ef3cbfa91976e343199d025907ac7f1ae0408bf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.physbeh.2008.01.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20454193$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18325546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avena, Nicole M</creatorcontrib><creatorcontrib>Bocarsly, Miriam E</creatorcontrib><creatorcontrib>Rada, Pedro</creatorcontrib><creatorcontrib>Kim, Agnes</creatorcontrib><creatorcontrib>Hoebel, Bartley G</creatorcontrib><title>After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Abstract Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintained on 12-h deprivation followed by 12-h access to a 10% sucrose solution and chow for 28 days, then fasted for 36 h. These animals spent less time on the exposed arm of an elevated plus-maze compared with a similarly deprived ad libitum chow group, suggesting anxiety. Microdialysis revealed a concomitant increase in extracellular acetylcholine and decrease in dopamine release in the nucleus accumbens shell. These results did not appear to be due to hypoglycemia. The findings suggest that a diet of bingeing on sucrose and chow followed by fasting creates a state that involves anxiety and altered accumbens dopamine and acetylcholine balance. This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders.</description><subject>Acetylcholine</subject><subject>Acetylcholine - metabolism</subject><subject>Adult and adolescent clinical studies</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Anxiety - etiology</subject><subject>Behavior, Animal</subject><subject>Behavioral psychophysiology</subject><subject>Binge eating</subject><subject>Bingeing</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Bulimia - complications</subject><subject>Dopamine</subject><subject>Dopamine - metabolism</subject><subject>Eating - physiology</subject><subject>Eating behavior disorders</subject><subject>Energy Intake - physiology</subject><subject>Feeding Behavior - physiology</subject><subject>Feeding Behavior - psychology</subject><subject>Food Deprivation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microdialysis</subject><subject>Miscellaneous</subject><subject>Nucleus accumbens</subject><subject>Nucleus Accumbens - metabolism</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sucrose</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1v1DAQjRCIbgs_AeQLnLpbO3YS59KqqviSKnEAJG6WY4-7XhJ7sZMVK_48E3ZVPi61ZI1sv3meN2-K4gWjK0ZZfbFZbdf73MF6VVIqV5StMDwqFkw2fFnR5uvjYkEpZ8uWS3FSnOa8obi44E-LEyZ5WVWiXhQ_r90IiVjt-z3pfLgD3CQGokmeTIoZSI79NPoYzomL0RIL2-R3er4hPtjJQCY6_PAw7jFaoo2Zhg5CJjZu9eADXGiDj71Zxx5PxA-d7nUw8Kx44nSf4fkxnhVf3r75fPN-efvx3Yeb69ulqSQbl07UNbXWOtZKqMpGc2lAlxU4bjqnW9Y2NaAu1raWllVLG20axzRQQWXnBD8rLg-826kbwBoIY9K9QhmDTnsVtVf_vgS_VndxpwSvhGw5Erw-EqT4fYI8qsFnAz2qgDhl1dCmFiV_GMjQjFqyGoHVATi3OCdw99UwqmZ_1UYd_VWzv4oyhQHzXv4t5U_W0VAEvDoCdDa6dwkb7fM9rqSiEuy3pKsDDrDxOw9JZeMBTbE-gRmVjf7BUi7_YzBor8dPv8Ee8iZOKaCriqlcKqo-zcM4zyKVOIaMcv4L0ZbfNw</recordid><startdate>20080609</startdate><enddate>20080609</enddate><creator>Avena, Nicole M</creator><creator>Bocarsly, Miriam E</creator><creator>Rada, Pedro</creator><creator>Kim, Agnes</creator><creator>Hoebel, Bartley G</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20080609</creationdate><title>After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance</title><author>Avena, Nicole M ; Bocarsly, Miriam E ; Rada, Pedro ; Kim, Agnes ; Hoebel, Bartley G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-f4660dddf198e527a38cea25ef3cbfa91976e343199d025907ac7f1ae0408bf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acetylcholine</topic><topic>Acetylcholine - metabolism</topic><topic>Adult and adolescent clinical studies</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Anxiety - etiology</topic><topic>Behavior, Animal</topic><topic>Behavioral psychophysiology</topic><topic>Binge eating</topic><topic>Bingeing</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Bulimia - complications</topic><topic>Dopamine</topic><topic>Dopamine - metabolism</topic><topic>Eating - physiology</topic><topic>Eating behavior disorders</topic><topic>Energy Intake - physiology</topic><topic>Feeding Behavior - physiology</topic><topic>Feeding Behavior - psychology</topic><topic>Food Deprivation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microdialysis</topic><topic>Miscellaneous</topic><topic>Nucleus accumbens</topic><topic>Nucleus Accumbens - metabolism</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sucrose</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avena, Nicole M</creatorcontrib><creatorcontrib>Bocarsly, Miriam E</creatorcontrib><creatorcontrib>Rada, Pedro</creatorcontrib><creatorcontrib>Kim, Agnes</creatorcontrib><creatorcontrib>Hoebel, Bartley G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avena, Nicole M</au><au>Bocarsly, Miriam E</au><au>Rada, Pedro</au><au>Kim, Agnes</au><au>Hoebel, Bartley G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>2008-06-09</date><risdate>2008</risdate><volume>94</volume><issue>3</issue><spage>309</spage><epage>315</epage><pages>309-315</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Abstract Bingeing on sugar may activate neural pathways in a manner similar to taking drugs of abuse, resulting in related signs of dependence. The present experiments test whether rats that have been bingeing on sucrose and then fasted demonstrate signs of opiate-like withdrawal. Rats were maintained on 12-h deprivation followed by 12-h access to a 10% sucrose solution and chow for 28 days, then fasted for 36 h. These animals spent less time on the exposed arm of an elevated plus-maze compared with a similarly deprived ad libitum chow group, suggesting anxiety. Microdialysis revealed a concomitant increase in extracellular acetylcholine and decrease in dopamine release in the nucleus accumbens shell. These results did not appear to be due to hypoglycemia. The findings suggest that a diet of bingeing on sucrose and chow followed by fasting creates a state that involves anxiety and altered accumbens dopamine and acetylcholine balance. This is similar to the effects of naloxone, suggesting opiate-like withdrawal. This may be a factor in some eating disorders.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18325546</pmid><doi>10.1016/j.physbeh.2008.01.008</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 2008-06, Vol.94 (3), p.309-315 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4354893 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acetylcholine Acetylcholine - metabolism Adult and adolescent clinical studies Analysis of Variance Animals Anxiety - etiology Behavior, Animal Behavioral psychophysiology Binge eating Bingeing Biological and medical sciences Blood Glucose Bulimia - complications Dopamine Dopamine - metabolism Eating - physiology Eating behavior disorders Energy Intake - physiology Feeding Behavior - physiology Feeding Behavior - psychology Food Deprivation Fundamental and applied biological sciences. Psychology Male Medical sciences Microdialysis Miscellaneous Nucleus accumbens Nucleus Accumbens - metabolism Psychiatry Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Psychopathology. Psychiatry Rats Rats, Sprague-Dawley Sucrose |
| title | After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T09%3A34%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=After%20daily%20bingeing%20on%20a%20sucrose%20solution,%20food%20deprivation%20induces%20anxiety%20and%20accumbens%20dopamine/acetylcholine%20imbalance&rft.jtitle=Physiology%20&%20behavior&rft.au=Avena,%20Nicole%20M&rft.date=2008-06-09&rft.volume=94&rft.issue=3&rft.spage=309&rft.epage=315&rft.pages=309-315&rft.issn=0031-9384&rft.eissn=1873-507X&rft_id=info:doi/10.1016/j.physbeh.2008.01.008&rft_dat=%3Cproquest_pubme%3E70764233%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=19386816&rft_id=info:pmid/18325546&rft_els_id=1_s2_0_S0031938408000103&rfr_iscdi=true |