Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy

Injury of the CA1 subregion induced by a single injection of kainic acid (1 × KA) in juvenile animals (P20) is attenuated in animals with two prior sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early‐life conditioning s...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The European journal of neuroscience 2013-07, Vol.38 (1), p.2139-2152
Hauptverfasser:	Friedman, L. K., Mancuso, J., Patel, A., Kudur, V., Leheste, J. R., Iacobas, S., Botta, J., Iacobas, D. A., Spray, D. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Biological and medical sciences CA1 Region, Hippocampal - metabolism calcium conditioning development Fundamental and applied biological sciences. Psychology Gene Expression Profiling Genetic Therapy Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy hippocampus Kainic Acid - toxicity Medical sciences microarray Nervous system (semeiology, syndromes) Neurology Rats Rats, Sprague-Dawley seizures Seizures - chemically induced Seizures - genetics Seizures - metabolism Seizures - therapy Transcription, Genetic Transcriptome Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!