Exogenous Superoxide Dismutase Mimetic Without Scavenging H2O2 Causes Photoreceptor Damage in a Rat Model for Oxygen-Induced Retinopathy

Frequent, brief intermittent episodes of hypoxia (IH) during hyperoxia increase reactive oxygen species in the immature retina with compromised antioxidant systems, thus leading to oxygen-induced retinopathy (OIR). We examined the hypothesis that early exposure to a mimetic of superoxide dismutase (...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2015-03, Vol.56 (3), p.1665-1677
Hauptverfasser:	Jivabhai Patel, Shamin, Bany-Mohammed, Fayez, McNally, Lois, Valencia, Gloria B, Lazzaro, Douglas R, Aranda, Jacob V, Beharry, Kay D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Disease Models, Animal Female Hydrogen Peroxide - metabolism Hyperoxia - physiopathology Hypoxia - physiopathology Male Metalloporphyrins - pharmacology Neovascularization, Pathologic - physiopathology Oxidative Phosphorylation Photoreceptor Cells, Vertebrate - physiology Pregnancy Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Retina - physiopathology Retinopathy of Prematurity - physiopathology Superoxide Dismutase - physiology
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