Piperlongumine reverses doxorubicin resistance through the PI3K/Akt signaling pathway in K562/A02 human leukemia cells

Drug resistance is an important obstacle to human leukemia therapeutics. Piperlongumine has previously demonstrated the ability to suppress certain human tumor processes; however, the ability of piperlongumine to reverse the drug resistance of human leukemia and its mechanism of action have not yet...

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Veröffentlicht in:	Experimental and therapeutic medicine 2015-04, Vol.9 (4), p.1345-1350
Hauptverfasser:	KANG, QINGWEI, YAN, SHU
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic agents Antineoplastic agents Apoptosis Bone marrow Care and treatment Cell cycle doxorubicin resistance Drug resistance Flow cytometry Gene expression human leukemia Kinases Leukemia Medical research Medicine, Experimental Phosphorylation piperlongumine Polymerase chain reaction Reactive oxygen species Signal transduction Stem cells
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