Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion
As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2015-04, Vol.9 (4), p.1460-1464 |
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| creator | LIU, YOUQING HAN, XIAOBING GAO, BAOAN |
| description | As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer. |
| doi_str_mv | 10.3892/etm.2015.2257 |
| format | Article |
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Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2015.2257</identifier><identifier>PMID: 25780452</identifier><language>eng</language><publisher>Greece: D.A. Spandidos</publisher><subject>Bladder cancer ; Cancer ; Cancer cells ; Cell growth ; Cell migration ; Development and progression ; Gene expression ; growth ; Immunoglobulins ; invasion ; Liver cancer ; Medical prognosis ; Metastasis ; migration ; Oncology, Experimental ; Ovarian cancer ; Proteins ; S100A11 ; Studies ; Thyroid cancer</subject><ispartof>Experimental and therapeutic medicine, 2015-04, Vol.9 (4), p.1460-1464</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><rights>Copyright © 2015, Spandidos Publications 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-3413e69f39b73aa146851d8e12710a45f27af38c85b44187912c620e9f1026d43</citedby><cites>FETCH-LOGICAL-c514t-3413e69f39b73aa146851d8e12710a45f27af38c85b44187912c620e9f1026d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353737/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4353737/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25780452$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIU, YOUQING</creatorcontrib><creatorcontrib>HAN, XIAOBING</creatorcontrib><creatorcontrib>GAO, BAOAN</creatorcontrib><title>Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>As a member of the S100 protein family, S100A11 expression is often upregulated in human cancer tissues. Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer.</description><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cancer cells</subject><subject>Cell growth</subject><subject>Cell migration</subject><subject>Development and progression</subject><subject>Gene expression</subject><subject>growth</subject><subject>Immunoglobulins</subject><subject>invasion</subject><subject>Liver cancer</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>migration</subject><subject>Oncology, Experimental</subject><subject>Ovarian cancer</subject><subject>Proteins</subject><subject>S100A11</subject><subject>Studies</subject><subject>Thyroid cancer</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptksuPFCEQh4nRuJtxj14NiQe99Ejx6IaLyWTjK25i4uNMGJqeZe2GFrpn9b-XdsbRNVIHKsVXBUX9EHoMZM2koi_cNKwpAbGmVDT30Dk0ilZQAvePPlESztBFzjekLFGDlOIhOiu0JFzQc_TxfYj2axtvA44d_gSEbACw-z4ml7OPAed5_OW7jOPeJG8CtiZYl7B1fY93Kd5O19iEFvuwN0vKI_SgM312F8d9hb68fvX58m119eHNu8vNVWUF8KliHJirVcfUtmHGAK-lgFY6oA0Qw0VHG9MxaaXYcg6yUUBtTYlTHRBat5yt0MtD3XHeDq61LkzJ9HpMfjDph47G67snwV_rXdxrzgRriq3Q82OBFL_NLk968HnpygQX56xB0rqmHEAU9Ok_6E2cUyjtaVCs_Hh5Xf2H2pneaR-6WO61S1G94UQ2kikBhVr_hyrWusHbGFznS_xOQnVIsCnmnFx36hGIXnSgiw70ogO96KDwT_7-mBP9e-oFeHYA8lgG59uYT0ypVERTEV6VgRD2Ezq1t_g</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>LIU, YOUQING</creator><creator>HAN, XIAOBING</creator><creator>GAO, BAOAN</creator><general>D.A. 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Numerous studies have demonstrated that S100A11 plays an important role in the progression of cancer. However, the function of S100A11 in ovarian cancer remains elusive. In the present study, the expression levels of S100A11 were found to be significantly increased in ovarian cancer cells. Subsequently, the expression of S100A11 in ovarian cancer HO8910 cells was knocked down using short hairpin (sh)RNA in order to investigate the biological effects of S100A11 on the progression of the disease. The results demonstrated that knockdown of S100A11 by shRNA inhibited the proliferation, anchorage-independent growth, invasion and migration of HO8910 cells. In addition, knockdown of S100A11 increased the expression of E-cadherin and decreased the expression of Snail in HO8910 cells. Collectively, these results indicated that S100A11 was able to promote the growth, invasion and migration of ovarian cancer cells. Therefore, S100A11 may serve as a potential molecular target for the diagnosis and treatment of ovarian cancer.</abstract><cop>Greece</cop><pub>D.A. Spandidos</pub><pmid>25780452</pmid><doi>10.3892/etm.2015.2257</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Bladder cancer Cancer Cancer cells Cell growth Cell migration Development and progression Gene expression growth Immunoglobulins invasion Liver cancer Medical prognosis Metastasis migration Oncology, Experimental Ovarian cancer Proteins S100A11 Studies Thyroid cancer |
| title | Knockdown of S100A11 expression suppresses ovarian cancer cell growth and invasion |
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