Crystal structure of afadin PDZ domain–nectin‐3 complex shows the structural plasticity of the ligand‐binding site

Afadin, a scaffold protein localized in adherens junctions (AJs), links nectins to the actin cytoskeleton. Nectins are the major cell adhesion molecules of AJs. At the initial stage of cell–cell junction formation, the nectin–afadin interaction plays an indispensable role in AJ biogenesis via recrui...

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Veröffentlicht in:	Protein science 2015-03, Vol.24 (3), p.376-385
Hauptverfasser:	Fujiwara, Yoshie, Goda, Natsuko, Tamashiro, Tomonari, Narita, Hirotaka, Satomura, Kaori, Tenno, Takeshi, Nakagawa, Atsushi, Oda, Masayuki, Suzuki, Mamoru, Sakisaka, Toshiaki, Takai, Yoshimi, Hiroaki, Hidekazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin adherens junction Adherens junctions afadin–nectin complex Amino acids Animals Binding Sites Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - metabolism Crystal structure crystallography Crystallography, X-Ray Crystals Cytoskeleton Dimers Fusion protein Hydrophobicity Ligands Mice Microfilament Proteins - chemistry Microfilament Proteins - metabolism Models, Molecular Nectin Nectins PDZ domain PDZ Domains Peptides Protein Binding Proteins Recombinant Proteins - chemistry Recombinant Proteins - metabolism Residues sequence specific recognition Tethering
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