DNA methylation at hepatitis B viral integrants is associated with methylation at flanking human genomic sequences

Integration of DNA viruses into the human genome plays an important role in various types of tumors, including hepatitis B virus (HBV)-related hepatocellular carcinoma. However, the molecular details and clinical impact of HBV integration on either human or HBV epigenomes are unknown. Here, we show...

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Veröffentlicht in:	Genome research 2015-03, Vol.25 (3), p.328-337
Hauptverfasser:	Watanabe, Yoshiyuki, Yamamoto, Hiroyuki, Oikawa, Ritsuko, Toyota, Minoru, Yamamoto, Masakazu, Kokudo, Norihiro, Tanaka, Shinji, Arii, Shigeki, Yotsuyanagi, Hiroshi, Koike, Kazuhiko, Itoh, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Alu Elements Carcinoma, Hepatocellular - genetics Cell Line, Tumor CpG Islands DNA Methylation DNA, Viral - genetics Epigenesis, Genetic Genetic Loci Genome, Human Genome, Viral Hepatitis B virus Hepatitis B virus - genetics High-Throughput Nucleotide Sequencing Humans In Situ Hybridization, Fluorescence Liver Neoplasms - genetics Virus Integration
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