The epidemiology of herpes zoster and its complications in Medicare cancer patients
Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years d...
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description | Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ.
Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported.
The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p |
doi_str_mv | 10.1186/s12879-015-0810-6 |
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Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported.
The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p <0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p <0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors.
Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. The rates of HZ and HZ-related complications are significantly higher for hematologic than solid cancer patients.</description><identifier>ISSN: 1471-2334</identifier><identifier>EISSN: 1471-2334</identifier><identifier>DOI: 10.1186/s12879-015-0810-6</identifier><identifier>PMID: 25888128</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Aged, 80 and over ; Analysis ; Biological products industry ; Cancer ; Distribution ; Female ; Health aspects ; Herpes Zoster - complications ; Herpes Zoster - economics ; Herpes Zoster - epidemiology ; Herpesvirus 3, Human ; Humans ; Incidence ; Longitudinal Studies ; Male ; Medicare ; Medicare - statistics & numerical data ; Neoplasms - complications ; Neoplasms - economics ; Neoplasms - epidemiology ; Oncology, Experimental ; Retrospective Studies ; Risk Factors ; SEER Program ; Statistics ; United States - epidemiology</subject><ispartof>BMC infectious diseases, 2015-02, Vol.15 (1), p.106-106, Article 106</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Yenikomshian et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b665t-71ae3856a6f12de1624594dd104e0e62a31505475805432181a173dbddb98d4a3</citedby><cites>FETCH-LOGICAL-b665t-71ae3856a6f12de1624594dd104e0e62a31505475805432181a173dbddb98d4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352235/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352235/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25888128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yenikomshian, Mihran A</creatorcontrib><creatorcontrib>Guignard, Adrienne P</creatorcontrib><creatorcontrib>Haguinet, François</creatorcontrib><creatorcontrib>LaCasce, Ann S</creatorcontrib><creatorcontrib>Skarin, Arthur T</creatorcontrib><creatorcontrib>Trahey, Alex</creatorcontrib><creatorcontrib>Karner, Paul</creatorcontrib><creatorcontrib>Duh, Mei Sheng</creatorcontrib><title>The epidemiology of herpes zoster and its complications in Medicare cancer patients</title><title>BMC infectious diseases</title><addtitle>BMC Infect Dis</addtitle><description>Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ.
Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported.
The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p <0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p <0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors.
Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. The rates of HZ and HZ-related complications are significantly higher for hematologic than solid cancer patients.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biological products industry</subject><subject>Cancer</subject><subject>Distribution</subject><subject>Female</subject><subject>Health aspects</subject><subject>Herpes Zoster - complications</subject><subject>Herpes Zoster - economics</subject><subject>Herpes Zoster - epidemiology</subject><subject>Herpesvirus 3, Human</subject><subject>Humans</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicare</subject><subject>Medicare - statistics & numerical data</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - economics</subject><subject>Neoplasms - epidemiology</subject><subject>Oncology, Experimental</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>SEER Program</subject><subject>Statistics</subject><subject>United States - epidemiology</subject><issn>1471-2334</issn><issn>1471-2334</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkl1r1jAUx4Mobk4_gDcS8EYvOnPy1vRGGPNtMBm46W1Im9PnibRNbfqI89Obh86xwgQJ5O38zj_JP4eQ58COAYx-k4CbsioYqIIZYIV-QA5BllBwIeTDO_MD8iSl74xBaXj1mBxwZYzJyYfk8mqLFMfgsQ-xi5trGlu6xWnERH_HNONE3eBpmBNtYj92oXFziEOiYaCf0eflhLRxQ5PBMYdwmNNT8qh1XcJnN-MR-frh_dXpp-L84uPZ6cl5UWut5qIEh8Io7XQL3CNoLlUlvQcmkaHmToBiSpbK5F5wMOCgFL72vq6Ml04ckbeL7rire_RNPntynR2n0Lvp2kYX7DoyhK3dxJ9WCsW5UFng3SJQh_gPgXUkW2AX02023e5NtzrLvLq5xxR_7DDNtg-pwa5zA8ZdsqBLqSuQTGb05YJuXIc2DG3Mus0etydKgqiYEDxTx_dQue1_qYkDtiHvrxJerxIyM-OveeN2Kdmzyy__z158W7OwsM0UU5qwvfUmP3xfgve68eLur9xm_K058Qcb8tTI</recordid><startdate>20150227</startdate><enddate>20150227</enddate><creator>Yenikomshian, Mihran A</creator><creator>Guignard, Adrienne P</creator><creator>Haguinet, François</creator><creator>LaCasce, Ann S</creator><creator>Skarin, Arthur T</creator><creator>Trahey, Alex</creator><creator>Karner, Paul</creator><creator>Duh, Mei Sheng</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150227</creationdate><title>The epidemiology of herpes zoster and its complications in Medicare cancer patients</title><author>Yenikomshian, Mihran A ; Guignard, Adrienne P ; Haguinet, François ; LaCasce, Ann S ; Skarin, Arthur T ; Trahey, Alex ; Karner, Paul ; Duh, Mei Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b665t-71ae3856a6f12de1624594dd104e0e62a31505475805432181a173dbddb98d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biological products industry</topic><topic>Cancer</topic><topic>Distribution</topic><topic>Female</topic><topic>Health aspects</topic><topic>Herpes Zoster - complications</topic><topic>Herpes Zoster - economics</topic><topic>Herpes Zoster - epidemiology</topic><topic>Herpesvirus 3, Human</topic><topic>Humans</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicare</topic><topic>Medicare - statistics & numerical data</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - economics</topic><topic>Neoplasms - epidemiology</topic><topic>Oncology, Experimental</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>SEER Program</topic><topic>Statistics</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yenikomshian, Mihran A</creatorcontrib><creatorcontrib>Guignard, Adrienne P</creatorcontrib><creatorcontrib>Haguinet, François</creatorcontrib><creatorcontrib>LaCasce, Ann S</creatorcontrib><creatorcontrib>Skarin, Arthur T</creatorcontrib><creatorcontrib>Trahey, Alex</creatorcontrib><creatorcontrib>Karner, Paul</creatorcontrib><creatorcontrib>Duh, Mei Sheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yenikomshian, Mihran A</au><au>Guignard, Adrienne P</au><au>Haguinet, François</au><au>LaCasce, Ann S</au><au>Skarin, Arthur T</au><au>Trahey, Alex</au><au>Karner, Paul</au><au>Duh, Mei Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The epidemiology of herpes zoster and its complications in Medicare cancer patients</atitle><jtitle>BMC infectious diseases</jtitle><addtitle>BMC Infect Dis</addtitle><date>2015-02-27</date><risdate>2015</risdate><volume>15</volume><issue>1</issue><spage>106</spage><epage>106</epage><pages>106-106</pages><artnum>106</artnum><issn>1471-2334</issn><eissn>1471-2334</eissn><abstract>Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ.
Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported.
The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p <0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p <0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors.
Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. The rates of HZ and HZ-related complications are significantly higher for hematologic than solid cancer patients.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25888128</pmid><doi>10.1186/s12879-015-0810-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Analysis Biological products industry Cancer Distribution Female Health aspects Herpes Zoster - complications Herpes Zoster - economics Herpes Zoster - epidemiology Herpesvirus 3, Human Humans Incidence Longitudinal Studies Male Medicare Medicare - statistics & numerical data Neoplasms - complications Neoplasms - economics Neoplasms - epidemiology Oncology, Experimental Retrospective Studies Risk Factors SEER Program Statistics United States - epidemiology |
title | The epidemiology of herpes zoster and its complications in Medicare cancer patients |
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