The epidemiology of herpes zoster and its complications in Medicare cancer patients

Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years d...

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Veröffentlicht in:BMC infectious diseases 2015-02, Vol.15 (1), p.106-106, Article 106
Hauptverfasser: Yenikomshian, Mihran A, Guignard, Adrienne P, Haguinet, François, LaCasce, Ann S, Skarin, Arthur T, Trahey, Alex, Karner, Paul, Duh, Mei Sheng
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container_title BMC infectious diseases
container_volume 15
creator Yenikomshian, Mihran A
Guignard, Adrienne P
Haguinet, François
LaCasce, Ann S
Skarin, Arthur T
Trahey, Alex
Karner, Paul
Duh, Mei Sheng
description Literature on the epidemiology of herpes zoster (HZ) in cancer patients is sparse and does not include the elderly. The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported. The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p
doi_str_mv 10.1186/s12879-015-0810-6
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The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported. The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p &lt;0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p &lt;0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors. Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. 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The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported. The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p &lt;0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p &lt;0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors. Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. 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The objectives of this study were to determine the incidence of HZ and related complications in elderly cancer patients and assess risk factors associated with HZ. Patients ≥65 years diagnosed with cancer in 1991-2007 were identified from the Surveillance, Epidemiology, and End Results (SEER) cancer registry-Medicare linked database in this retrospective, longitudinal, open cohort study. The observation period spanned from first cancer diagnosis until the end of data availability. A random group of non-cancer Medicare patients served as the comparison group. Cases of HZ and related complications were ascertained from medical claims. Incidence rates (IR) and adjusted IR ratios were reported. The study population consisted of 82,832 hematologic (HEM) and 944,777 solid cancer patients (SOLID). During follow-up, 9.2% of HEM and 6.3% of SOLID were diagnosed with HZ. The IR of HZ was significantly higher in HEM than SOLID (31.0 vs. 14.9 per 1,000 patient-years, p &lt;0.01). The adjusted IR ratio vs. non-cancer elderly patients was 2.4 in HEM and 1.2 in SOLID. The proportion of patients with complications was higher in HEM than SOLID (17.8% vs. 15.8%, p &lt;0.01). Age, gender, race, certain cancer therapies, and immunosuppression were HZ risk factors. Elderly cancer patients run a 1.2-2.4 times higher risk of developing HZ than those without cancer. The rates of HZ and HZ-related complications are significantly higher for hematologic than solid cancer patients.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25888128</pmid><doi>10.1186/s12879-015-0810-6</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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source Springer Open Access; MEDLINE; SpringerLink Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Freely accessible e-journals; PubMed Central; PubMed Central Open Access
subjects Aged
Aged, 80 and over
Analysis
Biological products industry
Cancer
Distribution
Female
Health aspects
Herpes Zoster - complications
Herpes Zoster - economics
Herpes Zoster - epidemiology
Herpesvirus 3, Human
Humans
Incidence
Longitudinal Studies
Male
Medicare
Medicare - statistics & numerical data
Neoplasms - complications
Neoplasms - economics
Neoplasms - epidemiology
Oncology, Experimental
Retrospective Studies
Risk Factors
SEER Program
Statistics
United States - epidemiology
title The epidemiology of herpes zoster and its complications in Medicare cancer patients
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