Developing a clinically feasible personalized medicine approach to pediatric septic shock

Using microarray data, we previously identified gene expression-based subclasses of septic shock with important phenotypic differences. The subclass-defining genes correspond to adaptive immunity and glucocorticoid receptor signaling. Identifying the subclasses in real time has theranostic implicati...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2015-02, Vol.191 (3), p.309-315
Hauptverfasser:	Wong, Hector R, Cvijanovich, Natalie Z, Anas, Nick, Allen, Geoffrey L, Thomas, Neal J, Bigham, Michael T, Weiss, Scott L, Fitzgerald, Julie, Checchia, Paul A, Meyer, Keith, Shanley, Thomas P, Quasney, Michael, Hall, Mark, Gedeit, Rainer, Freishtat, Robert J, Nowak, Jeffrey, Shekhar, Raj S, Gertz, Shira, Dawson, Emily, Howard, Kelli, Harmon, Kelli, Beckman, Eileen, Frank, Erin, Lindsell, Christopher J
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Child, Preschool Feasibility Studies Female Gene Expression Regulation Glucocorticoids - therapeutic use Humans Infant Intensive Care Units, Pediatric Male Mathematical Computing Odds Ratio Original Phenotype Precision Medicine Prospective Studies Reproducibility of Results Severity of Illness Index Shock, Septic - diagnosis Shock, Septic - genetics Shock, Septic - mortality Shock, Septic - therapy Signal Transduction - genetics
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