Maintenance of mouse hematopoietic stem cells ex vivo by reprogramming cellular metabolism

The difficulty in maintaining the reconstituting capabilities of hematopoietic stem cells (HSCs) in culture outside of the bone marrow microenvironment has severely limited their utilization for clinical therapy. This hurdle is largely due to the differentiation of long-term stem cells. Emerging evi...

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Veröffentlicht in:	Blood 2015-03, Vol.125 (10), p.1562-1565
Hauptverfasser:	Liu, Xia, Zheng, Hong, Yu, Wen-Mei, Cooper, Todd M., Bunting, Kevin D., Qu, Cheng-Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerobiosis - drug effects AMP-Activated Protein Kinases - metabolism Animals Biguanides - pharmacology Brief Report Cell Differentiation - drug effects Cells, Cultured Cellular Reprogramming - drug effects Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Glycolysis - drug effects Hematopoiesis and Stem Cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - metabolism Hypoglycemic Agents - pharmacology Metformin - pharmacology Mice Oxygen Consumption - drug effects PTEN Phosphohydrolase - antagonists & inhibitors
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