Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension
Few large-scale studies have evaluated the effectiveness of angiotensin receptor blockers in patients with masked hypertension (MH) and white coat hypertension (WCH) based on age using real-world blood pressure (BP) data. We used data from the Home BP measurement with Olmesartan Naive patients to Es...
Gespeichert in:
| Veröffentlicht in: | Hypertension research 2015-03, Vol.38 (3), p.178-185 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 185 |
|---|---|
| container_issue | 3 |
| container_start_page | 178 |
| container_title | Hypertension research |
| container_volume | 38 |
| creator | Kushiro, Toshio Kario, Kazuomi Saito, Ikuo Teramukai, Satoshi Mori, Yoshihiro Okuda, Yasuyuki Shimada, Kazuyuki |
| description | Few large-scale studies have evaluated the effectiveness of angiotensin receptor blockers in patients with masked hypertension (MH) and white coat hypertension (WCH) based on age using real-world blood pressure (BP) data. We used data from the Home BP measurement with Olmesartan Naive patients to Establish Standard Target BP (HONEST) study to investigate the effectiveness of olmesartan-based treatment by patient age ( |
| doi_str_mv | 10.1038/hr.2014.156 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351403</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1661328713</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-f1945211b0c4e7b3b5a7d8fe120b29faead5c79727258bafe718722432868b843</originalsourceid><addsrcrecordid>eNpVkU1rFTEUhoMo9ra6ci9ZCjLXfE4yG0FKtULBja5DkjlxojPJmOS23J_gv3YurUVXZ3HeL3gQekXJnhKu301lzwgVeyr7J2hHudCdYFQ8RTsy0L4bet6fofNafxDCtBzoc3TGJJdCKbVDv69CAN_iLSSoFeeA87xAtaXZ1DlbYcStgG0LpIZzwlNeANs0Yj_HFD12c84jXstmPhTAMWGYRyjzEa-2xc1U8V1sE15s_bllnZx3U2yAfbYNT8cVSoNUY04v0LNg5wovH-4F-vbx6uvldXfz5dPnyw83nRdEti7QQUhGqSNegHLcSatGHYAy4tgQLNhRejUoppjUzgZQVCvGBGe6104LfoHe3-euB7fA6LeNxc5mLXGx5Wiyjeb_T4qT-Z5vjeCSCsK3gDcPASX_OkBtZonVwzzbBPlQDe17urUpepK-vZf6kmstEB5rKDEneGYq5gTPbPA29et_lz1q_9LifwA3rpkG</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1661328713</pqid></control><display><type>article</type><title>Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><creator>Kushiro, Toshio ; Kario, Kazuomi ; Saito, Ikuo ; Teramukai, Satoshi ; Mori, Yoshihiro ; Okuda, Yasuyuki ; Shimada, Kazuyuki</creator><creatorcontrib>Kushiro, Toshio ; Kario, Kazuomi ; Saito, Ikuo ; Teramukai, Satoshi ; Mori, Yoshihiro ; Okuda, Yasuyuki ; Shimada, Kazuyuki</creatorcontrib><description>Few large-scale studies have evaluated the effectiveness of angiotensin receptor blockers in patients with masked hypertension (MH) and white coat hypertension (WCH) based on age using real-world blood pressure (BP) data. We used data from the Home BP measurement with Olmesartan Naive patients to Establish Standard Target BP (HONEST) study to investigate the effectiveness of olmesartan-based treatment by patient age (<65 years of age, n = 9817; 65-74 years of age, n = 6792; ⩾ 75 years of age, n = 4732), focusing on morning home BP (strongly associated with cardiovascular disease and useful for MH and WCH diagnosis). Sixteen weeks of treatment changed morning home BP (mean systolic/diastolic) by -18.1/-9.7, -15.9/-7.4 and -14.2/-6.4 mm Hg and clinic BP by -20.1/-11.3, -17.3/-8.7 and -15.4/-7.2 mm Hg, in these age groups, respectively (P < 0.0001). Pulse pressure decreased (-7.8 to -8.8 mm Hg, P < 0.0001). Patients aged ⩾ 80 years experienced similar BP and pulse pressure changes. In patients aged ⩾ 75 years, mean morning and clinic BP after 16 weeks was 137.5/74.8 and 129.7/70.4 mm Hg, respectively, in MH patients and 132.3/72.2 and 139.7/72.7 mm Hg, respectively, in WCH patients. Regardless of age, only elevated clinic or home BP values decreased to target ranges. The incidence of adverse effects associated with excessive BP lowering was low in all of the age groups. In conclusion, our study suggests that olmesartan-based treatment was safe and useful for managing MH, WCH and sustained hypertension in elderly patients. The lack of a placebo group was a limitation of the study.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/hr.2014.156</identifier><identifier>PMID: 25354777</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Angiotensin II Type 1 Receptor Blockers - pharmacology ; Angiotensin II Type 1 Receptor Blockers - therapeutic use ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Blood Pressure Monitoring, Ambulatory ; Circadian Rhythm - physiology ; Diastole - drug effects ; Diastole - physiology ; Female ; Follow-Up Studies ; Humans ; Imidazoles - pharmacology ; Imidazoles - therapeutic use ; Male ; Masked Hypertension - drug therapy ; Masked Hypertension - physiopathology ; Middle Aged ; Office Visits ; Original ; Prospective Studies ; Systole - drug effects ; Systole - physiology ; Tetrazoles - pharmacology ; Tetrazoles - therapeutic use ; Treatment Outcome ; White Coat Hypertension - drug therapy ; White Coat Hypertension - physiopathology</subject><ispartof>Hypertension research, 2015-03, Vol.38 (3), p.178-185</ispartof><rights>Copyright © 2015 The Japanese Society of Hypertension 2015 The Japanese Society of Hypertension</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-f1945211b0c4e7b3b5a7d8fe120b29faead5c79727258bafe718722432868b843</citedby><cites>FETCH-LOGICAL-c405t-f1945211b0c4e7b3b5a7d8fe120b29faead5c79727258bafe718722432868b843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25354777$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kushiro, Toshio</creatorcontrib><creatorcontrib>Kario, Kazuomi</creatorcontrib><creatorcontrib>Saito, Ikuo</creatorcontrib><creatorcontrib>Teramukai, Satoshi</creatorcontrib><creatorcontrib>Mori, Yoshihiro</creatorcontrib><creatorcontrib>Okuda, Yasuyuki</creatorcontrib><creatorcontrib>Shimada, Kazuyuki</creatorcontrib><title>Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Few large-scale studies have evaluated the effectiveness of angiotensin receptor blockers in patients with masked hypertension (MH) and white coat hypertension (WCH) based on age using real-world blood pressure (BP) data. We used data from the Home BP measurement with Olmesartan Naive patients to Establish Standard Target BP (HONEST) study to investigate the effectiveness of olmesartan-based treatment by patient age (<65 years of age, n = 9817; 65-74 years of age, n = 6792; ⩾ 75 years of age, n = 4732), focusing on morning home BP (strongly associated with cardiovascular disease and useful for MH and WCH diagnosis). Sixteen weeks of treatment changed morning home BP (mean systolic/diastolic) by -18.1/-9.7, -15.9/-7.4 and -14.2/-6.4 mm Hg and clinic BP by -20.1/-11.3, -17.3/-8.7 and -15.4/-7.2 mm Hg, in these age groups, respectively (P < 0.0001). Pulse pressure decreased (-7.8 to -8.8 mm Hg, P < 0.0001). Patients aged ⩾ 80 years experienced similar BP and pulse pressure changes. In patients aged ⩾ 75 years, mean morning and clinic BP after 16 weeks was 137.5/74.8 and 129.7/70.4 mm Hg, respectively, in MH patients and 132.3/72.2 and 139.7/72.7 mm Hg, respectively, in WCH patients. Regardless of age, only elevated clinic or home BP values decreased to target ranges. The incidence of adverse effects associated with excessive BP lowering was low in all of the age groups. In conclusion, our study suggests that olmesartan-based treatment was safe and useful for managing MH, WCH and sustained hypertension in elderly patients. The lack of a placebo group was a limitation of the study.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Angiotensin II Type 1 Receptor Blockers - pharmacology</subject><subject>Angiotensin II Type 1 Receptor Blockers - therapeutic use</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Circadian Rhythm - physiology</subject><subject>Diastole - drug effects</subject><subject>Diastole - physiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Imidazoles - pharmacology</subject><subject>Imidazoles - therapeutic use</subject><subject>Male</subject><subject>Masked Hypertension - drug therapy</subject><subject>Masked Hypertension - physiopathology</subject><subject>Middle Aged</subject><subject>Office Visits</subject><subject>Original</subject><subject>Prospective Studies</subject><subject>Systole - drug effects</subject><subject>Systole - physiology</subject><subject>Tetrazoles - pharmacology</subject><subject>Tetrazoles - therapeutic use</subject><subject>Treatment Outcome</subject><subject>White Coat Hypertension - drug therapy</subject><subject>White Coat Hypertension - physiopathology</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rFTEUhoMo9ra6ci9ZCjLXfE4yG0FKtULBja5DkjlxojPJmOS23J_gv3YurUVXZ3HeL3gQekXJnhKu301lzwgVeyr7J2hHudCdYFQ8RTsy0L4bet6fofNafxDCtBzoc3TGJJdCKbVDv69CAN_iLSSoFeeA87xAtaXZ1DlbYcStgG0LpIZzwlNeANs0Yj_HFD12c84jXstmPhTAMWGYRyjzEa-2xc1U8V1sE15s_bllnZx3U2yAfbYNT8cVSoNUY04v0LNg5wovH-4F-vbx6uvldXfz5dPnyw83nRdEti7QQUhGqSNegHLcSatGHYAy4tgQLNhRejUoppjUzgZQVCvGBGe6104LfoHe3-euB7fA6LeNxc5mLXGx5Wiyjeb_T4qT-Z5vjeCSCsK3gDcPASX_OkBtZonVwzzbBPlQDe17urUpepK-vZf6kmstEB5rKDEneGYq5gTPbPA29et_lz1q_9LifwA3rpkG</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Kushiro, Toshio</creator><creator>Kario, Kazuomi</creator><creator>Saito, Ikuo</creator><creator>Teramukai, Satoshi</creator><creator>Mori, Yoshihiro</creator><creator>Okuda, Yasuyuki</creator><creator>Shimada, Kazuyuki</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension</title><author>Kushiro, Toshio ; Kario, Kazuomi ; Saito, Ikuo ; Teramukai, Satoshi ; Mori, Yoshihiro ; Okuda, Yasuyuki ; Shimada, Kazuyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f1945211b0c4e7b3b5a7d8fe120b29faead5c79727258bafe718722432868b843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Angiotensin II Type 1 Receptor Blockers - pharmacology</topic><topic>Angiotensin II Type 1 Receptor Blockers - therapeutic use</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Blood Pressure Monitoring, Ambulatory</topic><topic>Circadian Rhythm - physiology</topic><topic>Diastole - drug effects</topic><topic>Diastole - physiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Imidazoles - pharmacology</topic><topic>Imidazoles - therapeutic use</topic><topic>Male</topic><topic>Masked Hypertension - drug therapy</topic><topic>Masked Hypertension - physiopathology</topic><topic>Middle Aged</topic><topic>Office Visits</topic><topic>Original</topic><topic>Prospective Studies</topic><topic>Systole - drug effects</topic><topic>Systole - physiology</topic><topic>Tetrazoles - pharmacology</topic><topic>Tetrazoles - therapeutic use</topic><topic>Treatment Outcome</topic><topic>White Coat Hypertension - drug therapy</topic><topic>White Coat Hypertension - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kushiro, Toshio</creatorcontrib><creatorcontrib>Kario, Kazuomi</creatorcontrib><creatorcontrib>Saito, Ikuo</creatorcontrib><creatorcontrib>Teramukai, Satoshi</creatorcontrib><creatorcontrib>Mori, Yoshihiro</creatorcontrib><creatorcontrib>Okuda, Yasuyuki</creatorcontrib><creatorcontrib>Shimada, Kazuyuki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kushiro, Toshio</au><au>Kario, Kazuomi</au><au>Saito, Ikuo</au><au>Teramukai, Satoshi</au><au>Mori, Yoshihiro</au><au>Okuda, Yasuyuki</au><au>Shimada, Kazuyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>38</volume><issue>3</issue><spage>178</spage><epage>185</epage><pages>178-185</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Few large-scale studies have evaluated the effectiveness of angiotensin receptor blockers in patients with masked hypertension (MH) and white coat hypertension (WCH) based on age using real-world blood pressure (BP) data. We used data from the Home BP measurement with Olmesartan Naive patients to Establish Standard Target BP (HONEST) study to investigate the effectiveness of olmesartan-based treatment by patient age (<65 years of age, n = 9817; 65-74 years of age, n = 6792; ⩾ 75 years of age, n = 4732), focusing on morning home BP (strongly associated with cardiovascular disease and useful for MH and WCH diagnosis). Sixteen weeks of treatment changed morning home BP (mean systolic/diastolic) by -18.1/-9.7, -15.9/-7.4 and -14.2/-6.4 mm Hg and clinic BP by -20.1/-11.3, -17.3/-8.7 and -15.4/-7.2 mm Hg, in these age groups, respectively (P < 0.0001). Pulse pressure decreased (-7.8 to -8.8 mm Hg, P < 0.0001). Patients aged ⩾ 80 years experienced similar BP and pulse pressure changes. In patients aged ⩾ 75 years, mean morning and clinic BP after 16 weeks was 137.5/74.8 and 129.7/70.4 mm Hg, respectively, in MH patients and 132.3/72.2 and 139.7/72.7 mm Hg, respectively, in WCH patients. Regardless of age, only elevated clinic or home BP values decreased to target ranges. The incidence of adverse effects associated with excessive BP lowering was low in all of the age groups. In conclusion, our study suggests that olmesartan-based treatment was safe and useful for managing MH, WCH and sustained hypertension in elderly patients. The lack of a placebo group was a limitation of the study.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>25354777</pmid><doi>10.1038/hr.2014.156</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0916-9636 |
| ispartof | Hypertension research, 2015-03, Vol.38 (3), p.178-185 |
| issn | 0916-9636 1348-4214 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4351403 |
| source | MEDLINE; Alma/SFX Local Collection; EZB Electronic Journals Library |
| subjects | Age Factors Aged Aged, 80 and over Angiotensin II Type 1 Receptor Blockers - pharmacology Angiotensin II Type 1 Receptor Blockers - therapeutic use Blood Pressure - drug effects Blood Pressure - physiology Blood Pressure Monitoring, Ambulatory Circadian Rhythm - physiology Diastole - drug effects Diastole - physiology Female Follow-Up Studies Humans Imidazoles - pharmacology Imidazoles - therapeutic use Male Masked Hypertension - drug therapy Masked Hypertension - physiopathology Middle Aged Office Visits Original Prospective Studies Systole - drug effects Systole - physiology Tetrazoles - pharmacology Tetrazoles - therapeutic use Treatment Outcome White Coat Hypertension - drug therapy White Coat Hypertension - physiopathology |
| title | Effectiveness of olmesartan-based treatment on home and clinic blood pressure in elderly patients with masked and white coat hypertension |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T23%3A09%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effectiveness%20of%20olmesartan-based%20treatment%20on%20home%20and%20clinic%20blood%20pressure%20in%20elderly%20patients%20with%20masked%20and%20white%20coat%20hypertension&rft.jtitle=Hypertension%20research&rft.au=Kushiro,%20Toshio&rft.date=2015-03-01&rft.volume=38&rft.issue=3&rft.spage=178&rft.epage=185&rft.pages=178-185&rft.issn=0916-9636&rft.eissn=1348-4214&rft_id=info:doi/10.1038/hr.2014.156&rft_dat=%3Cproquest_pubme%3E1661328713%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1661328713&rft_id=info:pmid/25354777&rfr_iscdi=true |