The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes
Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical a...
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description | Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical aspects of these procedures, such as restriction and malabsorption, a growing body of evidence from mouse models of these procedures points to physiological changes that mediate the potent effects of these surgeries. In particular, there are similar changes in gut hormone secretion, bile acid levels, and composition after both of these procedures. Moreover, loss of function of the nuclear bile acid receptor (FXR) greatly diminishes the effects of VSG. Both VSG and RYGB are linked to profound changes in the gut microbiome that also mediate at least some of these surgical effects. We hypothesize that surgical rearrangement of the gastrointestinal tract results in enteroplasticity caused by the high rate of nutrient presentation and altered pH in the small intestine that contribute to these physiological effects. Identifying the molecular underpinnings of these procedures provides new opportunities to understand the relationship of the gastrointestinal tract to obesity and diabetes as well as new therapeutic strategies to harness the effectiveness of surgery with less-invasive approaches.
•Bariatric surgery is highly effective for treating obesity and diabetes•These surgeries alter gut function, resulting in effects on weight and metabolism•Gut adaptation contributes to the effects of these surgeries on energy balance
Various bariatric surgery procedures are the most potent treatments for both obesity and type 2 diabetes. This is not a result of mechanical restriction or malabsorption, but rather a result of alterations in gut function and signaling. Hypotheses about these physiological changes are presented in this review. |
doi_str_mv | 10.1016/j.cmet.2015.01.001 |
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•Bariatric surgery is highly effective for treating obesity and diabetes•These surgeries alter gut function, resulting in effects on weight and metabolism•Gut adaptation contributes to the effects of these surgeries on energy balance
Various bariatric surgery procedures are the most potent treatments for both obesity and type 2 diabetes. This is not a result of mechanical restriction or malabsorption, but rather a result of alterations in gut function and signaling. Hypotheses about these physiological changes are presented in this review.</description><identifier>ISSN: 1550-4131</identifier><identifier>EISSN: 1932-7420</identifier><identifier>DOI: 10.1016/j.cmet.2015.01.001</identifier><identifier>PMID: 25662404</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adaptation, Physiological - physiology ; Animals ; Bariatric Surgery - methods ; Body Weight - physiology ; Diabetes Mellitus - physiopathology ; Diabetes Mellitus - surgery ; Food ; Gastrointestinal Tract - physiology ; Humans ; Obesity - physiopathology ; Obesity - surgery</subject><ispartof>Cell metabolism, 2015-03, Vol.21 (3), p.369-378</ispartof><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><rights>2015 Elsevier Inc. All rights reserved 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-5678d6bf7bee63c33799414262dd8b0cf8861ca0752cfe9e749c354c70eb6b1c3</citedby><cites>FETCH-LOGICAL-c521t-5678d6bf7bee63c33799414262dd8b0cf8861ca0752cfe9e749c354c70eb6b1c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cmet.2015.01.001$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,315,781,785,886,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25662404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seeley, Randy J.</creatorcontrib><creatorcontrib>Chambers, Adam P.</creatorcontrib><creatorcontrib>Sandoval, Darleen A.</creatorcontrib><title>The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes</title><title>Cell metabolism</title><addtitle>Cell Metab</addtitle><description>Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical aspects of these procedures, such as restriction and malabsorption, a growing body of evidence from mouse models of these procedures points to physiological changes that mediate the potent effects of these surgeries. In particular, there are similar changes in gut hormone secretion, bile acid levels, and composition after both of these procedures. Moreover, loss of function of the nuclear bile acid receptor (FXR) greatly diminishes the effects of VSG. Both VSG and RYGB are linked to profound changes in the gut microbiome that also mediate at least some of these surgical effects. We hypothesize that surgical rearrangement of the gastrointestinal tract results in enteroplasticity caused by the high rate of nutrient presentation and altered pH in the small intestine that contribute to these physiological effects. Identifying the molecular underpinnings of these procedures provides new opportunities to understand the relationship of the gastrointestinal tract to obesity and diabetes as well as new therapeutic strategies to harness the effectiveness of surgery with less-invasive approaches.
•Bariatric surgery is highly effective for treating obesity and diabetes•These surgeries alter gut function, resulting in effects on weight and metabolism•Gut adaptation contributes to the effects of these surgeries on energy balance
Various bariatric surgery procedures are the most potent treatments for both obesity and type 2 diabetes. This is not a result of mechanical restriction or malabsorption, but rather a result of alterations in gut function and signaling. Hypotheses about these physiological changes are presented in this review.</description><subject>Adaptation, Physiological - physiology</subject><subject>Animals</subject><subject>Bariatric Surgery - methods</subject><subject>Body Weight - physiology</subject><subject>Diabetes Mellitus - physiopathology</subject><subject>Diabetes Mellitus - surgery</subject><subject>Food</subject><subject>Gastrointestinal Tract - physiology</subject><subject>Humans</subject><subject>Obesity - physiopathology</subject><subject>Obesity - surgery</subject><issn>1550-4131</issn><issn>1932-7420</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtr3DAQx0VpaNKkX6CHomMvdjV6eQ2lkKZpWkhIyOMsZHmc1eK1NpIcyLevlk1De8lJgv9jhvkR8hFYDQz0l1Xt1phrzkDVDGrG4A05gFbwqpGcvS1_pVglQcA-eZ_SijGhRSvekX2utOaSyQOyvF0ivQ4j0jDQsznT495uss0-TNRPNBf1KmScMj0dBnQ5bX0X85j9pmS-2-htjt7RmzneY_RY9Iledph8fqJ26ukPbzvMmI7I3mDHhB-e30Ny9_P09uRXdX559vvk-LxyikOulG4Wve6GpkPUwgnRtK0EyTXv-0XH3LBYaHCWNYq7AVtsZOuEkq5h2OkOnDgk33a9m7lbY-_K6tGOZhP92sYnE6w3_yuTX5r78GikUFAOVgo-PxfE8DBjymbtk8NxtBOGORnQZaZmrZbFyndWF0NKEYeXMcDMFpFZmS0is0VkGJiCqIQ-_bvgS-Qvk2L4ujNgOdOjx2iS8zg57H0sBEwf_Gv9fwBG9qOJ</recordid><startdate>20150303</startdate><enddate>20150303</enddate><creator>Seeley, Randy J.</creator><creator>Chambers, Adam P.</creator><creator>Sandoval, Darleen A.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150303</creationdate><title>The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes</title><author>Seeley, Randy J. ; Chambers, Adam P. ; Sandoval, Darleen A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-5678d6bf7bee63c33799414262dd8b0cf8861ca0752cfe9e749c354c70eb6b1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adaptation, Physiological - physiology</topic><topic>Animals</topic><topic>Bariatric Surgery - methods</topic><topic>Body Weight - physiology</topic><topic>Diabetes Mellitus - physiopathology</topic><topic>Diabetes Mellitus - surgery</topic><topic>Food</topic><topic>Gastrointestinal Tract - physiology</topic><topic>Humans</topic><topic>Obesity - physiopathology</topic><topic>Obesity - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seeley, Randy J.</creatorcontrib><creatorcontrib>Chambers, Adam P.</creatorcontrib><creatorcontrib>Sandoval, Darleen A.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seeley, Randy J.</au><au>Chambers, Adam P.</au><au>Sandoval, Darleen A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes</atitle><jtitle>Cell metabolism</jtitle><addtitle>Cell Metab</addtitle><date>2015-03-03</date><risdate>2015</risdate><volume>21</volume><issue>3</issue><spage>369</spage><epage>378</epage><pages>369-378</pages><issn>1550-4131</issn><eissn>1932-7420</eissn><abstract>Bariatric surgical procedures such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) are the most potent treatments available to produce sustained reductions in body weight and improvements in glucose regulation. While traditionally these effects are attributed to mechanical aspects of these procedures, such as restriction and malabsorption, a growing body of evidence from mouse models of these procedures points to physiological changes that mediate the potent effects of these surgeries. In particular, there are similar changes in gut hormone secretion, bile acid levels, and composition after both of these procedures. Moreover, loss of function of the nuclear bile acid receptor (FXR) greatly diminishes the effects of VSG. Both VSG and RYGB are linked to profound changes in the gut microbiome that also mediate at least some of these surgical effects. We hypothesize that surgical rearrangement of the gastrointestinal tract results in enteroplasticity caused by the high rate of nutrient presentation and altered pH in the small intestine that contribute to these physiological effects. Identifying the molecular underpinnings of these procedures provides new opportunities to understand the relationship of the gastrointestinal tract to obesity and diabetes as well as new therapeutic strategies to harness the effectiveness of surgery with less-invasive approaches.
•Bariatric surgery is highly effective for treating obesity and diabetes•These surgeries alter gut function, resulting in effects on weight and metabolism•Gut adaptation contributes to the effects of these surgeries on energy balance
Various bariatric surgery procedures are the most potent treatments for both obesity and type 2 diabetes. This is not a result of mechanical restriction or malabsorption, but rather a result of alterations in gut function and signaling. Hypotheses about these physiological changes are presented in this review.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25662404</pmid><doi>10.1016/j.cmet.2015.01.001</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adaptation, Physiological - physiology Animals Bariatric Surgery - methods Body Weight - physiology Diabetes Mellitus - physiopathology Diabetes Mellitus - surgery Food Gastrointestinal Tract - physiology Humans Obesity - physiopathology Obesity - surgery |
title | The Role of Gut Adaptation in the Potent Effects of Multiple Bariatric Surgeries on Obesity and Diabetes |
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