Distinct Conformational Spectrum of Homologous Multidrug ABC Transporters

ATP-binding cassette (ABC) exporters are ubiquitously found in all kingdoms of life and their members play significant roles in mediating drug pharmacokinetics and multidrug resistance in the clinic. Significant questions and controversies remain regarding the relevance of their conformations observ...

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Veröffentlicht in:	Structure (London) 2015-03, Vol.23 (3), p.450-460
Hauptverfasser:	Moeller, Arne, Lee, Sung Chang, Tao, Houchao, Speir, Jeffrey A., Chang, Geoffrey, Urbatsch, Ina L., Potter, Clinton S., Carragher, Bridget, Zhang, Qinghai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP-Binding Cassette Transporters - chemistry ATP-Binding Cassette Transporters - ultrastructure ATP-Binding Cassette, Sub-Family B, Member 1 - chemistry Bacterial Proteins - chemistry Bacterial Proteins - ultrastructure Membrane Lipids - chemistry Mice Microscopy, Electron Models, Molecular Nucleotides - chemistry Protein Binding Protein Conformation Protein Stability Structural Homology, Protein
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