Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury
Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acu...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2015-03, Vol.92 (3), p.611-616 |
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| container_title | The American journal of tropical medicine and hygiene |
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| creator | Libório, Alexandre Braga Braz, Marcelo Boecker Munoz Seguro, Antonio Carlos Meneses, Gdayllon C Neves, Fernanda Macedo de Oliveira Pedrosa, Danielle Carvalho Cavalcanti, Luciano Pamplona de Góes Martins, Alice Maria Costa Daher, Elizabeth de Francesco |
| description | Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage. |
| doi_str_mv | 10.4269/ajtmh.14-0232 |
| format | Article |
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Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.14-0232</identifier><identifier>PMID: 25624405</identifier><language>eng</language><publisher>United States: The American Society of Tropical Medicine and Hygiene</publisher><subject>Acute Kidney Injury - epidemiology ; Acute Kidney Injury - etiology ; Acute Kidney Injury - pathology ; Adolescent ; Biomarkers ; Brazil - epidemiology ; Disease Outbreaks ; Endothelium - pathology ; Glycocalyx - pathology ; Humans ; Inflammation ; Leptospira ; Leptospirosis - epidemiology ; Leptospirosis - pathology ; Male ; Military Personnel ; Oxidative Stress ; Young Adult</subject><ispartof>The American journal of tropical medicine and hygiene, 2015-03, Vol.92 (3), p.611-616</ispartof><rights>The American Society of Tropical Medicine and Hygiene.</rights><rights>The American Society of Tropical Medicine and Hygiene 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-8359fe3c20b94f79093ab10cb718534cae7395a2896d0cadcc23286201b34c6a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350560/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350560/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25624405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Libório, Alexandre Braga</creatorcontrib><creatorcontrib>Braz, Marcelo Boecker Munoz</creatorcontrib><creatorcontrib>Seguro, Antonio Carlos</creatorcontrib><creatorcontrib>Meneses, Gdayllon C</creatorcontrib><creatorcontrib>Neves, Fernanda Macedo de Oliveira</creatorcontrib><creatorcontrib>Pedrosa, Danielle Carvalho</creatorcontrib><creatorcontrib>Cavalcanti, Luciano Pamplona de Góes</creatorcontrib><creatorcontrib>Martins, Alice Maria Costa</creatorcontrib><creatorcontrib>Daher, Elizabeth de Francesco</creatorcontrib><title>Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>Leptospirosis is a common disease in tropical countries, and the kidney is one of the main target organs. Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. This association remained even after multivariate analysis including other AKI-associated characteristics. Endothelial injury biomarkers are associated with leptospirosis-associated renal damage.</description><subject>Acute Kidney Injury - epidemiology</subject><subject>Acute Kidney Injury - etiology</subject><subject>Acute Kidney Injury - pathology</subject><subject>Adolescent</subject><subject>Biomarkers</subject><subject>Brazil - epidemiology</subject><subject>Disease Outbreaks</subject><subject>Endothelium - pathology</subject><subject>Glycocalyx - pathology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leptospira</subject><subject>Leptospirosis - epidemiology</subject><subject>Leptospirosis - pathology</subject><subject>Male</subject><subject>Military Personnel</subject><subject>Oxidative Stress</subject><subject>Young Adult</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv2zAQhIkiQe04PfZa6JiLkuVT0iVAEeQFGAgQJGdiRdE2XUp0RCqt_n3lPIz2tIf5MLuzQ8h3CueCqeoCt6ndnFORA-PsC5lTUaicKiGPyBwAWF4pXszISYxbAFoySr-SGZOKCQFyTh6vuyakjfUOfbb2owkG_fgna7DFtc1czDDGYBwm22S_Xdpk3u5SiDvXh7hXzZBs9ss1nR0z122Hfjwlxyv00X77mAvyfHP9dHWXLx9u769-LnMjGKS85LJaWW4Y1JVYFRVUHGsKpi5oKbkwaAteSWRlpRow2BgzBSwVA1pPqkK-IJfvvruhbm1jbJd69HrXuxb7UQd0-n-lcxu9Dq9acAlSwWRw9mHQh5fBxqRbF431HjsbhqhpwRgtFEg-ofk7aqbYsberwxoKet-DfutBU6H3PUz8j39vO9Cfj-d_ARX3hpQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Libório, Alexandre Braga</creator><creator>Braz, Marcelo Boecker Munoz</creator><creator>Seguro, Antonio Carlos</creator><creator>Meneses, Gdayllon C</creator><creator>Neves, Fernanda Macedo de Oliveira</creator><creator>Pedrosa, Danielle Carvalho</creator><creator>Cavalcanti, Luciano Pamplona de Góes</creator><creator>Martins, Alice Maria Costa</creator><creator>Daher, Elizabeth de Francesco</creator><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury</title><author>Libório, Alexandre Braga ; 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Membrane proteins of Leptospira are capable of causing endothelial damage in vitro, but there have been no studies in humans evaluating endothelial glycocalyx damage and its correlation with acute kidney injury (AKI). We performed a cohort study in an outbreak of leptospirosis among military personnel. AKI was diagnosed in 14 of 46 (30.4%) patients. Leptospirosis was associated with higher levels of intercellular adhesion molecule-1 (ICAM-1; 483.1 ± 31.7 versus 234.9 ± 24.4 mg/L, P < 0.001) and syndecan-1 (73.7 ± 15.9 versus 21.2 ± 7.9 ng/mL, P < 0.001) compared with exposed controls. Patients with leptospirosis-associated AKI had increased level of syndecan-1 (112.1 ± 45.4 versus 41.5 ± 11.7 ng/mL, P = 0.021) and ICAM-1 (576.9 ± 70.4 versus 434.9 ± 35.3, P = 0.034) compared with leptospirosis patients with no AKI. Association was verified between syndecan-1 and ICAM-1 with serum creatinine elevation and neutrophil gelatinase-associated lipocalin (NGAL) levels. 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| subjects | Acute Kidney Injury - epidemiology Acute Kidney Injury - etiology Acute Kidney Injury - pathology Adolescent Biomarkers Brazil - epidemiology Disease Outbreaks Endothelium - pathology Glycocalyx - pathology Humans Inflammation Leptospira Leptospirosis - epidemiology Leptospirosis - pathology Male Military Personnel Oxidative Stress Young Adult |
| title | Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury |
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