The role of AXL and the in vitro activity of the receptor tyrosine kinase inhibitor BGB324 in Ewing sarcoma

New targets for Ewing sarcoma (ES) patients are urgently needed. Therefore, we investigated the expression and genetic aberrations of the oncogenic receptor tyrosine kinase (RTK) AXL in ES and determined the efficacy of AXL targeting on cell viability and migration. First, AXL and Gas6 (ligand) mRNA...

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Veröffentlicht in:	Oncotarget 2014-12, Vol.5 (24), p.12753-12768
Hauptverfasser:	Fleuren, Emmy D G, Hillebrandt-Roeffen, Melissa H S, Flucke, Uta E, Te Loo, D Maroeska W M, Boerman, Otto C, van der Graaf, Winette T A, Versleijen-Jonkers, Yvonne M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Benzocycloheptenes - pharmacology Cell Survival - drug effects Child Child, Preschool Female Humans In Vitro Techniques Intercellular Signaling Peptides and Proteins - biosynthesis Intercellular Signaling Peptides and Proteins - genetics Male Middle Aged Prognosis Protein Kinase Inhibitors - pharmacology Proto-Oncogene Proteins - antagonists & inhibitors Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Receptor Protein-Tyrosine Kinases - antagonists & inhibitors Receptor Protein-Tyrosine Kinases - biosynthesis Receptor Protein-Tyrosine Kinases - genetics Receptor Protein-Tyrosine Kinases - metabolism Research Paper RNA, Messenger - biosynthesis RNA, Messenger - genetics Sarcoma, Ewing - drug therapy Sarcoma, Ewing - enzymology Triazoles - pharmacology Young Adult
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