Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status

The presence of cancer stem cells (CSCs) is linked to preexisting or acquired drug resistance and tumor relapse. Therefore, targeting both differentiated tumor cells and CSCs was suggested as an effective approach for non-small cell lung cancer (NSCLC) treatment. After screening of chemotherapeutic...

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Veröffentlicht in:	Oncotarget 2014-12, Vol.5 (24), p.12877-12890
Hauptverfasser:	Xiao, Zhiguang, Sperl, Bianca, Ullrich, Axel, Knyazev, Pjotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Metformin - administration & dosage Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - pathology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins p21(ras) Pyrans - administration & dosage ras Proteins - genetics ras Proteins - metabolism Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Research Paper Serine Endopeptidases - genetics Serine Endopeptidases - metabolism Signal Transduction
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