A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-asso...
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| Veröffentlicht in: | World journal of surgical oncology 2015-02, Vol.13 (1), p.67-67, Article 67 |
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| creator | Ohta, Miho Moriyama, Masafumi Goto, Yuichi Kawano, Shintaro Tanaka, Akihiko Maehara, Takashi Furukawa, Sachiko Hayashida, Jun-Nosuke Kiyoshima, Tamotsu Shimizu, Mayumi Arinobu, Yojiro Nakamura, Seiji |
| description | IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease).
We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.
Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case. |
| doi_str_mv | 10.1186/s12957-015-0459-z |
| format | Article |
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We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.
Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/s12957-015-0459-z</identifier><identifier>PMID: 25889621</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Care and treatment ; Case Report ; Case studies ; Castleman Disease - blood ; Castleman Disease - diagnosis ; Castleman Disease - surgery ; Dacryocystitis ; Dacryocystitis - blood ; Dacryocystitis - diagnosis ; Dacryocystitis - surgery ; Development and progression ; Diagnosis ; Diagnosis, Differential ; Granulomatosis with Polyangiitis - blood ; Granulomatosis with Polyangiitis - diagnosis ; Granulomatosis with Polyangiitis - surgery ; Humans ; Immunoglobulin G ; Immunoglobulin G - blood ; Lymphoma, B-Cell, Marginal Zone - blood ; Lymphoma, B-Cell, Marginal Zone - diagnosis ; Lymphoma, B-Cell, Marginal Zone - surgery ; Lymphomas ; Male ; Mikulicz' Disease - blood ; Mikulicz' Disease - diagnosis ; Mikulicz' Disease - surgery ; Prognosis ; Sialadenitis - blood ; Sialadenitis - diagnosis ; Sialadenitis - surgery ; Sjogren's Syndrome - blood ; Sjogren's Syndrome - diagnosis ; Sjogren's Syndrome - surgery</subject><ispartof>World journal of surgical oncology, 2015-02, Vol.13 (1), p.67-67, Article 67</ispartof><rights>COPYRIGHT 2015 BioMed Central Ltd.</rights><rights>Ohta et al.; licensee BioMed Central. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c563t-746b8ed1b69d9235c302c675f839ba8524ef02831b7da7f01ad0eae33d47e5913</citedby><cites>FETCH-LOGICAL-c563t-746b8ed1b69d9235c302c675f839ba8524ef02831b7da7f01ad0eae33d47e5913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4350294/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25889621$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohta, Miho</creatorcontrib><creatorcontrib>Moriyama, Masafumi</creatorcontrib><creatorcontrib>Goto, Yuichi</creatorcontrib><creatorcontrib>Kawano, Shintaro</creatorcontrib><creatorcontrib>Tanaka, Akihiko</creatorcontrib><creatorcontrib>Maehara, Takashi</creatorcontrib><creatorcontrib>Furukawa, Sachiko</creatorcontrib><creatorcontrib>Hayashida, Jun-Nosuke</creatorcontrib><creatorcontrib>Kiyoshima, Tamotsu</creatorcontrib><creatorcontrib>Shimizu, Mayumi</creatorcontrib><creatorcontrib>Arinobu, Yojiro</creatorcontrib><creatorcontrib>Nakamura, Seiji</creatorcontrib><title>A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease).
We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.
Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.</description><subject>Aged</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Castleman Disease - blood</subject><subject>Castleman Disease - diagnosis</subject><subject>Castleman Disease - surgery</subject><subject>Dacryocystitis</subject><subject>Dacryocystitis - blood</subject><subject>Dacryocystitis - diagnosis</subject><subject>Dacryocystitis - surgery</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Granulomatosis with Polyangiitis - blood</subject><subject>Granulomatosis with Polyangiitis - diagnosis</subject><subject>Granulomatosis with Polyangiitis - surgery</subject><subject>Humans</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin G - blood</subject><subject>Lymphoma, B-Cell, Marginal Zone - blood</subject><subject>Lymphoma, B-Cell, Marginal Zone - diagnosis</subject><subject>Lymphoma, B-Cell, Marginal Zone - surgery</subject><subject>Lymphomas</subject><subject>Male</subject><subject>Mikulicz' Disease - blood</subject><subject>Mikulicz' Disease - diagnosis</subject><subject>Mikulicz' Disease - surgery</subject><subject>Prognosis</subject><subject>Sialadenitis - blood</subject><subject>Sialadenitis - diagnosis</subject><subject>Sialadenitis - surgery</subject><subject>Sjogren's Syndrome - blood</subject><subject>Sjogren's Syndrome - diagnosis</subject><subject>Sjogren's Syndrome - surgery</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptUsGKFDEUDKK46-gHeJGAIF56TTpJp3MRxkXXhQUveg7p5HVPNJ2MnR5h5utNM-swA5JDwktVvfeKQug1JTeUts2HTGslZEWoqAgXqjo8QdeUS1nJlqqnZ-8r9CLnn4TUjAn2HF3Vom1VU9NrpNfYmgw49Xg00-CjCfiQIuBP2EIIOOzH7SaNBo9-9PaXjwO-H-54NUEwMzjsjJ32yTiIfvYZm-hw9iacKi_Rs96EDK8e7xX68eXz99uv1cO3u_vb9UNlRcPmSvKma8HRrlFO1UxYRmrbSNG3THWmFTWHntQto510RvaEGkfAAGOOSxCKshX6eNTd7roRnIU4Tybo7eTLWnudjNeXP9Fv9JD-aM4EqRUvAu8fBab0ewd51qPPiwUmQtplTZsyY6sEW3q9PUIHE0D72KeiaBe4XgtOBWGyjLpCN_9BleOgOFks7n2pXxDenRE2YMK8ySnsZp9ivgTSI9BOKecJ-tOalOglGPoYDF2CoZdg6EPhvDn358T4lwT2F_rssyA</recordid><startdate>20150221</startdate><enddate>20150221</enddate><creator>Ohta, Miho</creator><creator>Moriyama, Masafumi</creator><creator>Goto, Yuichi</creator><creator>Kawano, Shintaro</creator><creator>Tanaka, Akihiko</creator><creator>Maehara, Takashi</creator><creator>Furukawa, Sachiko</creator><creator>Hayashida, Jun-Nosuke</creator><creator>Kiyoshima, Tamotsu</creator><creator>Shimizu, Mayumi</creator><creator>Arinobu, Yojiro</creator><creator>Nakamura, Seiji</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150221</creationdate><title>A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis</title><author>Ohta, Miho ; Moriyama, Masafumi ; Goto, Yuichi ; Kawano, Shintaro ; Tanaka, Akihiko ; Maehara, Takashi ; Furukawa, Sachiko ; Hayashida, Jun-Nosuke ; Kiyoshima, Tamotsu ; Shimizu, Mayumi ; Arinobu, Yojiro ; Nakamura, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-746b8ed1b69d9235c302c675f839ba8524ef02831b7da7f01ad0eae33d47e5913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Castleman Disease - blood</topic><topic>Castleman Disease - diagnosis</topic><topic>Castleman Disease - surgery</topic><topic>Dacryocystitis</topic><topic>Dacryocystitis - blood</topic><topic>Dacryocystitis - diagnosis</topic><topic>Dacryocystitis - surgery</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Granulomatosis with Polyangiitis - blood</topic><topic>Granulomatosis with Polyangiitis - diagnosis</topic><topic>Granulomatosis with Polyangiitis - surgery</topic><topic>Humans</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulin G - blood</topic><topic>Lymphoma, B-Cell, Marginal Zone - blood</topic><topic>Lymphoma, B-Cell, Marginal Zone - diagnosis</topic><topic>Lymphoma, B-Cell, Marginal Zone - surgery</topic><topic>Lymphomas</topic><topic>Male</topic><topic>Mikulicz' Disease - blood</topic><topic>Mikulicz' Disease - diagnosis</topic><topic>Mikulicz' Disease - surgery</topic><topic>Prognosis</topic><topic>Sialadenitis - blood</topic><topic>Sialadenitis - diagnosis</topic><topic>Sialadenitis - surgery</topic><topic>Sjogren's Syndrome - blood</topic><topic>Sjogren's Syndrome - diagnosis</topic><topic>Sjogren's Syndrome - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohta, Miho</creatorcontrib><creatorcontrib>Moriyama, Masafumi</creatorcontrib><creatorcontrib>Goto, Yuichi</creatorcontrib><creatorcontrib>Kawano, Shintaro</creatorcontrib><creatorcontrib>Tanaka, Akihiko</creatorcontrib><creatorcontrib>Maehara, Takashi</creatorcontrib><creatorcontrib>Furukawa, Sachiko</creatorcontrib><creatorcontrib>Hayashida, Jun-Nosuke</creatorcontrib><creatorcontrib>Kiyoshima, Tamotsu</creatorcontrib><creatorcontrib>Shimizu, Mayumi</creatorcontrib><creatorcontrib>Arinobu, Yojiro</creatorcontrib><creatorcontrib>Nakamura, Seiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohta, Miho</au><au>Moriyama, Masafumi</au><au>Goto, Yuichi</au><au>Kawano, Shintaro</au><au>Tanaka, Akihiko</au><au>Maehara, Takashi</au><au>Furukawa, Sachiko</au><au>Hayashida, Jun-Nosuke</au><au>Kiyoshima, Tamotsu</au><au>Shimizu, Mayumi</au><au>Arinobu, Yojiro</au><au>Nakamura, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2015-02-21</date><risdate>2015</risdate><volume>13</volume><issue>1</issue><spage>67</spage><epage>67</epage><pages>67-67</pages><artnum>67</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS), so-called Mikulicz's disease, is characterized by elevated serum IgG4 and infiltration of IgG4-positive plasma cells in glandular tissues. Recently, several studies reported both malignant lymphoma developed on the background of IgG4-associated conditions and IgG4-producing malignant lymphoma (non-IgG4-related disease).
We report on the case of a 70-year-old man who was strongly suspected IgG4-DS because of high serum IgG4 concentration (215 mg/dl) and bilateral swelling of parotid and submandibular glands. Biopsies of cervical lymph node and a portion of submandibular gland were performed. These histopathological findings subsequently confirmed a diagnosis of marginal zone B cell lymphoma.
Differential diagnosis of IgG4-DS is necessary from other disorders, including Sjögren's syndrome, sarcoidosis, Castleman's disease, Wegener's granulomatosis, lymphoma, and cancer. We suggest that biopsy of swollen lesions is important for a definitive diagnosis of IgG4-DS and discuss the mechanism of development in this case.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>25889621</pmid><doi>10.1186/s12957-015-0459-z</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Care and treatment Case Report Case studies Castleman Disease - blood Castleman Disease - diagnosis Castleman Disease - surgery Dacryocystitis Dacryocystitis - blood Dacryocystitis - diagnosis Dacryocystitis - surgery Development and progression Diagnosis Diagnosis, Differential Granulomatosis with Polyangiitis - blood Granulomatosis with Polyangiitis - diagnosis Granulomatosis with Polyangiitis - surgery Humans Immunoglobulin G Immunoglobulin G - blood Lymphoma, B-Cell, Marginal Zone - blood Lymphoma, B-Cell, Marginal Zone - diagnosis Lymphoma, B-Cell, Marginal Zone - surgery Lymphomas Male Mikulicz' Disease - blood Mikulicz' Disease - diagnosis Mikulicz' Disease - surgery Prognosis Sialadenitis - blood Sialadenitis - diagnosis Sialadenitis - surgery Sjogren's Syndrome - blood Sjogren's Syndrome - diagnosis Sjogren's Syndrome - surgery |
| title | A case of marginal zone B cell lymphoma mimicking IgG4-related dacryoadenitis and sialoadenitis |
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