New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

Using whole-cell phenotypic assays, the GlaxoSmithKline high-throughput screening (HTS) diversity set of 1.8 million compounds was screened against the three kinetoplastids most relevant to human disease, i.e. Leishmania donovani , Trypanosoma cruzi and Trypanosoma brucei . Secondary confirmatory an...

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Veröffentlicht in:	Scientific reports 2015-03, Vol.5 (1), p.8771-8771, Article 8771
Hauptverfasser:	Peña, Imanol, Pilar Manzano, M., Cantizani, Juan, Kessler, Albane, Alonso-Padilla, Julio, Bardera, Ana I., Alvarez, Emilio, Colmenarejo, Gonzalo, Cotillo, Ignacio, Roquero, Irene, de Dios-Anton, Francisco, Barroso, Vanessa, Rodriguez, Ana, Gray, David W., Navarro, Miguel, Kumar, Vinod, Sherstnev, Alexander, Drewry, David H., Brown, James R., Fiandor, Jose M., Julio Martin, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/19 38/47 49/98 631/154/1435/2163 631/326/417 Animals Antiprotozoal Agents - pharmacology Bioinformatics Cell Line Cytotoxicity Drug Evaluation, Preclinical - methods Genome, Protozoan High-throughput screening High-Throughput Screening Assays Humanities and Social Sciences Humans Kinetoplastida - classification Kinetoplastida - drug effects Kinetoplastida - genetics Mice multidisciplinary Parasites Parasitic Sensitivity Tests - methods Phylogeny Physicochemical properties Protozoa Science Small Molecule Libraries
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