Yhhu981, a novel compound, stimulates fatty acid oxidation via the activation of AMPK and ameliorates lipid metabolism disorder in ob/ob mice

Aim： Defects in fatty acid metabolism contribute to the pathogenesis of insulin resistance and obesity. In this study, we investigated the effects of a novel compound yhhu981 on fatty acid metabolism in vitro and in vivo. Methods： The capacity to stimulate fatty acid oxidation was assessed in C2C12...

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Veröffentlicht in:	Acta pharmacologica Sinica 2015-03, Vol.36 (3), p.343-352
Hauptverfasser:	Zeng, Hong-liang, Huang, Su-ling, Xie, Fu-chun, Zeng, Li-min, Hu, You-hong, Leng, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - metabolism Alkynes - pharmacology AMP-Activated Protein Kinases - antagonists & inhibitors AMP-Activated Protein Kinases - metabolism AMPK Animals Anti-Obesity Agents - pharmacology Biomedical and Life Sciences Biomedicine Disease Models, Animal Dose-Response Relationship, Drug Energy Metabolism - drug effects Enzyme Activation Enzyme Activators - pharmacology Fatty Acids - metabolism Hep G2 Cells HepG2细胞 Humans Immunology Internal Medicine Liver - drug effects Liver - enzymology Medical Microbiology Mice, Obese Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - enzymology Obesity - drug therapy Obesity - enzymology Original original-article Oxidation-Reduction Pharmacology/Toxicology Phosphorylation Protein Kinase Inhibitors - pharmacology Resorcinols - pharmacology Signal Transduction - drug effects Up-Regulation Vaccine 代谢紊乱化合物小鼠脂肪酸合成脂肪酸氧化脂质代谢
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