TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice

Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disorder with no effective medical treatments available. The generation of myofibroblasts, which are critical for fibrogenesis, requires both a mechanical signal and activated TGF-β; however, it is not clear how fibroblasts sense and trans...

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Veröffentlicht in:	The Journal of clinical investigation 2014-12, Vol.124 (12), p.5225-5238
Hauptverfasser:	Rahaman, Shaik O, Grove, Lisa M, Paruchuri, Sailaja, Southern, Brian D, Abraham, Susamma, Niese, Kathryn A, Scheraga, Rachel G, Ghosh, Sudakshina, Thodeti, Charles K, Zhang, David X, Moran, Magdalene M, Schilling, William P, Tschumperlin, Daniel J, Olman, Mitchell A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - adverse effects Antibiotics, Antineoplastic - pharmacology Biomedical research Bleomycin - adverse effects Bleomycin - pharmacology Cell Differentiation Cell growth Collagen Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Fibroblasts Gene expression Genes Genetic aspects Heart Hydrogels Kinases Lung - metabolism Lung - pathology Mice Mice, Mutant Strains Myofibroblasts - metabolism Myofibroblasts - pathology Physiological aspects Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - genetics Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Rodents Trans-Activators - genetics Trans-Activators - metabolism Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism TRPV Cation Channels - biosynthesis TRPV Cation Channels - genetics Up-Regulation
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