Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci
The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. Recently, subtle differences in the expression of the two alleles have been detected in numerous human genes and in a few cases, have been asso...
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| Veröffentlicht in: | Oncogene 2009-09, Vol.28 (38), p.3345-3348 |
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| description | The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. Recently, subtle differences in the expression of the two alleles have been detected in numerous human genes and in a few cases, have been associated with a genetic predisposition to disease. The underlying mechanisms are largely unexplored. |
| doi_str_mv | 10.1038/onc.2009.194 |
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Psychology ; Gene Expression ; Genetic Predisposition to Disease ; Genetic susceptibility ; Genomic imprinting ; Human Genetics ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Molecular and cellular biology ; Oncology ; Polymorphism, Single Nucleotide ; Quantitative trait loci ; Regulatory Elements, Transcriptional ; review</subject><ispartof>Oncogene, 2009-09, Vol.28 (38), p.3345-3348</ispartof><rights>Macmillan Publishers Limited 2009</rights><rights>2009 INIST-CNRS</rights><rights>COPYRIGHT 2009 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Sep 24, 2009</rights><rights>Macmillan Publishers Limited 2009.</rights><rights>2009 Macmillan Publishers Limited All rights reserved 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c669t-1ad115452cefd59b056d0c0d6693c3795fdc0be2065bb8c5c5a4e03fdbf66df83</citedby><cites>FETCH-LOGICAL-c669t-1ad115452cefd59b056d0c0d6693c3795fdc0be2065bb8c5c5a4e03fdbf66df83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/onc.2009.194$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/onc.2009.194$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22013587$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19597467$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de la Chapelle, A</creatorcontrib><title>Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. Recently, subtle differences in the expression of the two alleles have been detected in numerous human genes and in a few cases, have been associated with a genetic predisposition to disease. The underlying mechanisms are largely unexplored.</description><subject>Alleles</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Cell Biology</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Chromosome Mapping</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic susceptibility</subject><subject>Genomic imprinting</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular and cellular biology</subject><subject>Oncology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quantitative trait loci</subject><subject>Regulatory Elements, Transcriptional</subject><subject>review</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFks9rFDEUxwdR7LZ68yyDUk_Omt8z8SCUolUoeNFzyCQv25TZZExmqv3vzbBL10pFcgi893nf94NvVb3AaI0R7d7FYNYEIbnGkj2qVpi1ouFcssfVCkmOGkkoOaqOc75GCLUSkafVEZZctky0q8pdQIDJm3pMYH0eY_aTj6GeYn01b3WoSxB0hve1HgYYoMkjGO9KAfwqJTkvsA62HuLPZly0kg4G6gSbedBTTLclY_yz6onTQ4bn-_-k-v7p47fzz83l14sv52eXjRFCTg3WFmPOODHgLJc94sIig2xJUkNbyZ01qAeCBO_7znDDNQNEne2dENZ19KT6sNMd534L1kAo8wxqTH6r062K2qv7meCv1CbeKEZZJ2RbBN7sBVL8MUOe1NZnA8OgA8Q5K9EKIVgZ538gwZR0iKMCvv4LvI5zCuUKigiGaddyIgr16p8UaSlrOywOUhs9gPLBxbKDWfqqM4IkZRLzZYX1A1R5FrbexADOl_i9gre7ApNizgnc3b0wUovHVPGYWjymiscK_vLPGx_gvakKcLoHdDZ6cIsjfL7jCEGY8m7hmh2XSypsIB12frDxb_pS6TU</recordid><startdate>20090924</startdate><enddate>20090924</enddate><creator>de la Chapelle, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090924</creationdate><title>Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci</title><author>de la Chapelle, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-1ad115452cefd59b056d0c0d6693c3795fdc0be2065bb8c5c5a4e03fdbf66df83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Alleles</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Cell Biology</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Chromosome Mapping</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic susceptibility</topic><topic>Genomic imprinting</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular and cellular biology</topic><topic>Oncology</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Quantitative trait loci</topic><topic>Regulatory Elements, Transcriptional</topic><topic>review</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de la Chapelle, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de la Chapelle, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2009-09-24</date><risdate>2009</risdate><volume>28</volume><issue>38</issue><spage>3345</spage><epage>3348</epage><pages>3345-3348</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>The two alleles of a gene can be expressed at different levels, the extreme example being imprinting, a condition in which one allele is totally suppressed. 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| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SpringerLink Journals - AutoHoldings |
| subjects | Alleles Apoptosis Biological and medical sciences Cancer Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chromosome Mapping Colorectal Neoplasms - genetics Fundamental and applied biological sciences. Psychology Gene Expression Genetic Predisposition to Disease Genetic susceptibility Genomic imprinting Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Molecular and cellular biology Oncology Polymorphism, Single Nucleotide Quantitative trait loci Regulatory Elements, Transcriptional review |
| title | Genetic predisposition to human disease: allele-specific expression and low-penetrance regulatory loci |
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