Macrophage polarization in response to ECM coated polypropylene mesh

Abstract The host response to implanted biomaterials is a highly regulated process that influences device functionality and clinical outcome. Non-degradable biomaterials, such as knitted polypropylene mesh, frequently elicit a chronic foreign body reaction with resultant fibrosis. Previous studies h...

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Veröffentlicht in:	Biomaterials 2014-08, Vol.35 (25), p.6838-6849
Hauptverfasser:	Wolf, Matthew T, Dearth, Christopher L, Ranallo, Christian A, LoPresti, Samuel T, Carey, Lisa E, Daly, Kerry A, Brown, Bryan N, Badylak, Stephen F
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals biocompatible materials Biomaterials Biomedical materials bladder Coated Materials, Biocompatible - chemistry Coating coatings Dentistry dermis ECM (extracellular matrix) Electrochemical machining extracellular matrix Extracellular Matrix - chemistry Female fibrosis Fibrosis - pathology Foreign bodies Foreign-Body Reaction giant cells Hydrogel hydrogels Hydrogels - chemistry Immunity, Innate - drug effects Macrophage Macrophages Macrophages - chemistry Materials Testing mechanism of action Polypropylene Polypropylenes Polypropylenes - chemistry Prostheses and Implants Rats Rats, Sprague-Dawley Surgical implants Surgical Mesh Ventral hernia
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