Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

Chronic graft-versus-host disease (cGVHD) is a life-threatening impediment to allogeneic hematopoietic stem cell transplantation, and current therapies do not completely prevent and/or treat cGVHD. CD4+ T cells and B cells mediate cGVHD; therefore, targeting these populations may inhibit cGVHD patho...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2014-11, Vol.124 (11), p.4867-4876
Hauptverfasser:	Dubovsky, Jason A, Flynn, Ryan, Du, Jing, Harrington, Bonnie K, Zhong, Yiming, Kaffenberger, Benjamin, Yang, Carrie, Towns, William H, Lehman, Amy, Johnson, Amy J, Muthusamy, Natarajan, Devine, Steven M, Jaglowski, Samantha, Serody, Jonathan S, Murphy, William J, Munn, David H, Luznik, Leo, Hill, Geoffrey R, Wong, Henry K, MacDonald, Kelli K P, Maillard, Ivan, Koreth, John, Elias, Laurence, Cutler, Corey, Soiffer, Robert J, Antin, Joseph H, Ritz, Jerome, Panoskaltsis-Mortari, Angela, Byrd, John C, Blazar, Bruce R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical research Disease-Free Survival Drug Evaluation, Preclinical Drug therapy Graft versus host reaction Graft vs Host Disease - drug therapy Hematopoietic Stem Cell Transplantation - adverse effects Immune system Immunologic Factors - pharmacology Immunologic Factors - therapeutic use Kinases Lymphocyte Activation - drug effects Lymphocytes Mice, Inbred C57BL Physiological aspects Pyrazoles - pharmacology Pyrazoles - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Skin Studies T cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!