Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome act...

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Veröffentlicht in:	Nature communications 2015-02, Vol.6 (1), p.6115-6115, Article 6115
Hauptverfasser:	Yang, Chul-Su, Kim, Jwa-Jin, Kim, Tae Sung, Lee, Phil Young, Kim, Soo Yeon, Lee, Hye-Mi, Shin, Dong-Min, Nguyen, Loi T., Lee, Moo-Seung, Jin, Hyo Sun, Kim, Kwang-Kyu, Lee, Chul-Ho, Kim, Myung Hee, Park, Sung Goo, Kim, Jin-Man, Choi, Hueng-Sik, Jo, Eun-Kyeong
Format:	Artikel
Sprache:	eng
Schlagworte:	13 631/250/256/2177 631/250/262/2106/2517 631/337/475/2290 64 64/60 82 82/58 82/80 96 96/95 Animals Apoptosis Regulatory Proteins - metabolism CARD Signaling Adaptor Proteins Carrier Proteins - metabolism Caspase 1 - metabolism Endoplasmic Reticulum - metabolism Enzyme Activation HEK293 Cells Homeostasis Humanities and Social Sciences Humans Inflammasomes - metabolism Interleukin-1beta - metabolism Mice, Inbred C57BL Mitochondria - metabolism multidisciplinary NLR Family, Pyrin Domain-Containing 3 Protein Protein Binding Protein Transport Receptors, Cytoplasmic and Nuclear - deficiency Receptors, Cytoplasmic and Nuclear - metabolism Science Science (multidisciplinary)
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