Dopamine regulates distinctively the activity patterns of striatal output neurons in advanced parkinsonian primates

Nigrostriatal dopamine denervation plays a major role in basal ganglia circuitry disarray and motor abnormalities of Parkinson's disease (PD). Studies in rodent and primate models have revealed that striatal projection neurons, namely, medium spiny neurons (MSNs), increase the firing frequency....

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Veröffentlicht in:	Journal of neurophysiology 2015-03, Vol.113 (5), p.1533-1544
Hauptverfasser:	Singh, Arun, Liang, Li, Kaneoke, Yoshiki, Cao, Xuebing, Papa, Stella M
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Corpus Striatum - cytology Corpus Striatum - metabolism Corpus Striatum - physiopathology Dopamine - metabolism Dopamine Agents - pharmacology Female Levodopa - pharmacology Macaca mulatta MPTP Poisoning - metabolism MPTP Poisoning - physiopathology Neural Circuits Neurons - drug effects Neurons - metabolism Neurons - physiology Receptors, Dopamine D2 - metabolism
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