Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study
Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their a...
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| creator | Robbins, Jeremy M., MD Petrone, Andrew B., MPH Carr, J. Jeffrey, MD, MSc Pankow, James S., MPH, PhD Hunt, Steven C., PhD Heiss, Gerardo, MD, MSc, PhD Arnett, Donna K., PhD, MSPH Ellison, R. Curtis, MD Gaziano, J. Michael, MD Djoussé, Luc, MD, DSc |
| description | Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease. We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods In a cross-sectional design, we studied 1,731 predominantly white men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent coronary heart disease. Diet was assessed by a semiquantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results Mean age was 56.8 years, and 41% were male. The median number of ideal CVH metrics was 3, and no participant met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29-0.45), 0.35 (0.26-0.44), and 0.27 (0.20-0.36) among subjects with 0 to 1, 2, 3, and 4+ ideal CVH metrics, respectively ( P = .0001), adjusting for sex, age, field center, alcohol, income, education, and energy consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women. |
| doi_str_mv | 10.1016/j.ahj.2014.12.017 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4346707</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002870315000071</els_id><sourcerecordid>3607571371</sourcerecordid><originalsourceid>FETCH-LOGICAL-c604t-2689e50aebd2929f36666830e142e30137d282202809c692ad5fc1731550a9013</originalsourceid><addsrcrecordid>eNp9Us1u1DAQjhCILoUH4IIsceHQLLaT2AlIlUpFaaUVHFrOlmtPul688dZ2VtpX4imZdEuBHsghsf39jGfyFcVrRueMMvF-NdfL1ZxTVs8Zn1MmnxQzRjtZClnXT4sZpZSXraTVQfEipRVuBW_F8-KAN5K3kstZ8fMkpWCczi4MJPTEWdCeGB2tC1udzOh1JEs8y0uiB4uIN653YInOS4ghGY_v7AzZeH07AnEDQYCYEMOg447omCE6SB_IFR5_vSuEFc4BgSOyGIebozvjTz4ESy6GlF0eM5AzvXZ-t-eRyzza3cviWa99glf338Pi-9nnq9PzcvHty8XpyaI0gta55KLtoKEari3veNdXAp-2osBqDhVllbS85ZzylnZGdFzbpjdMVqxBUYf4YXG8992M12uwBoYctVeb6NbYkAraqX-RwS3VTdiquqqFpBIN3t0bxIAjSVmtXTLgvR4gjEkxgRdlklcVUt8-oq7CGHFAE6tppag4m1hszzI48BShf7gMo2pKglopTIKakqAYV5gE1Lz5u4sHxe9fj4SPewLgLLcOokrGwWDAuggmKxvcf-2PH6mNd4PDePyAHaQ_XaiEAnU5RXFKImtwRSWrfgGvFdol</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1658763213</pqid></control><display><type>article</type><title>Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Robbins, Jeremy M., MD ; Petrone, Andrew B., MPH ; Carr, J. Jeffrey, MD, MSc ; Pankow, James S., MPH, PhD ; Hunt, Steven C., PhD ; Heiss, Gerardo, MD, MSc, PhD ; Arnett, Donna K., PhD, MSPH ; Ellison, R. Curtis, MD ; Gaziano, J. Michael, MD ; Djoussé, Luc, MD, DSc</creator><creatorcontrib>Robbins, Jeremy M., MD ; Petrone, Andrew B., MPH ; Carr, J. Jeffrey, MD, MSc ; Pankow, James S., MPH, PhD ; Hunt, Steven C., PhD ; Heiss, Gerardo, MD, MSc, PhD ; Arnett, Donna K., PhD, MSPH ; Ellison, R. Curtis, MD ; Gaziano, J. Michael, MD ; Djoussé, Luc, MD, DSc</creatorcontrib><description>Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease. We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods In a cross-sectional design, we studied 1,731 predominantly white men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent coronary heart disease. Diet was assessed by a semiquantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results Mean age was 56.8 years, and 41% were male. The median number of ideal CVH metrics was 3, and no participant met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29-0.45), 0.35 (0.26-0.44), and 0.27 (0.20-0.36) among subjects with 0 to 1, 2, 3, and 4+ ideal CVH metrics, respectively ( P = .0001), adjusting for sex, age, field center, alcohol, income, education, and energy consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/j.ahj.2014.12.017</identifier><identifier>PMID: 25728727</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Atherosclerosis ; Blood Glucose - analysis ; Blood Pressure ; Body mass index ; Cardiovascular ; Cardiovascular disease ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Cardiovascular Physiological Phenomena ; Cholesterol ; Coronary Vessels - pathology ; Cross-Sectional Studies ; Epidemiology ; Family medical history ; Female ; Glucose ; Health Behavior ; Health care ; Health risk assessment ; Health Status ; Heart ; Humans ; Hypertension ; Laboratories ; Male ; Middle Aged ; Mortality ; Nutrition research ; Physical fitness ; Plaque, Atherosclerotic - epidemiology ; Population ; Public health ; Questionnaires ; Smoking ; Studies ; Vascular Calcification - pathology</subject><ispartof>The American heart journal, 2015-03, Vol.169 (3), p.371-378.e1</ispartof><rights>2015</rights><rights>Published by Elsevier Inc.</rights><rights>Copyright Elsevier Limited Mar 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c604t-2689e50aebd2929f36666830e142e30137d282202809c692ad5fc1731550a9013</citedby><cites>FETCH-LOGICAL-c604t-2689e50aebd2929f36666830e142e30137d282202809c692ad5fc1731550a9013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002870315000071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25728727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robbins, Jeremy M., MD</creatorcontrib><creatorcontrib>Petrone, Andrew B., MPH</creatorcontrib><creatorcontrib>Carr, J. Jeffrey, MD, MSc</creatorcontrib><creatorcontrib>Pankow, James S., MPH, PhD</creatorcontrib><creatorcontrib>Hunt, Steven C., PhD</creatorcontrib><creatorcontrib>Heiss, Gerardo, MD, MSc, PhD</creatorcontrib><creatorcontrib>Arnett, Donna K., PhD, MSPH</creatorcontrib><creatorcontrib>Ellison, R. Curtis, MD</creatorcontrib><creatorcontrib>Gaziano, J. Michael, MD</creatorcontrib><creatorcontrib>Djoussé, Luc, MD, DSc</creatorcontrib><title>Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study</title><title>The American heart journal</title><addtitle>Am Heart J</addtitle><description>Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease. We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods In a cross-sectional design, we studied 1,731 predominantly white men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent coronary heart disease. Diet was assessed by a semiquantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results Mean age was 56.8 years, and 41% were male. The median number of ideal CVH metrics was 3, and no participant met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29-0.45), 0.35 (0.26-0.44), and 0.27 (0.20-0.36) among subjects with 0 to 1, 2, 3, and 4+ ideal CVH metrics, respectively ( P = .0001), adjusting for sex, age, field center, alcohol, income, education, and energy consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women.</description><subject>Atherosclerosis</subject><subject>Blood Glucose - analysis</subject><subject>Blood Pressure</subject><subject>Body mass index</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cardiovascular Physiological Phenomena</subject><subject>Cholesterol</subject><subject>Coronary Vessels - pathology</subject><subject>Cross-Sectional Studies</subject><subject>Epidemiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Glucose</subject><subject>Health Behavior</subject><subject>Health care</subject><subject>Health risk assessment</subject><subject>Health Status</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Laboratories</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nutrition research</subject><subject>Physical fitness</subject><subject>Plaque, Atherosclerotic - epidemiology</subject><subject>Population</subject><subject>Public health</subject><subject>Questionnaires</subject><subject>Smoking</subject><subject>Studies</subject><subject>Vascular Calcification - pathology</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9Us1u1DAQjhCILoUH4IIsceHQLLaT2AlIlUpFaaUVHFrOlmtPul688dZ2VtpX4imZdEuBHsghsf39jGfyFcVrRueMMvF-NdfL1ZxTVs8Zn1MmnxQzRjtZClnXT4sZpZSXraTVQfEipRVuBW_F8-KAN5K3kstZ8fMkpWCczi4MJPTEWdCeGB2tC1udzOh1JEs8y0uiB4uIN653YInOS4ghGY_v7AzZeH07AnEDQYCYEMOg447omCE6SB_IFR5_vSuEFc4BgSOyGIebozvjTz4ESy6GlF0eM5AzvXZ-t-eRyzza3cviWa99glf338Pi-9nnq9PzcvHty8XpyaI0gta55KLtoKEari3veNdXAp-2osBqDhVllbS85ZzylnZGdFzbpjdMVqxBUYf4YXG8992M12uwBoYctVeb6NbYkAraqX-RwS3VTdiquqqFpBIN3t0bxIAjSVmtXTLgvR4gjEkxgRdlklcVUt8-oq7CGHFAE6tppag4m1hszzI48BShf7gMo2pKglopTIKakqAYV5gE1Lz5u4sHxe9fj4SPewLgLLcOokrGwWDAuggmKxvcf-2PH6mNd4PDePyAHaQ_XaiEAnU5RXFKImtwRSWrfgGvFdol</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Robbins, Jeremy M., MD</creator><creator>Petrone, Andrew B., MPH</creator><creator>Carr, J. 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Jeffrey, MD, MSc ; Pankow, James S., MPH, PhD ; Hunt, Steven C., PhD ; Heiss, Gerardo, MD, MSc, PhD ; Arnett, Donna K., PhD, MSPH ; Ellison, R. Curtis, MD ; Gaziano, J. 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Jeffrey, MD, MSc</au><au>Pankow, James S., MPH, PhD</au><au>Hunt, Steven C., PhD</au><au>Heiss, Gerardo, MD, MSc, PhD</au><au>Arnett, Donna K., PhD, MSPH</au><au>Ellison, R. Curtis, MD</au><au>Gaziano, J. Michael, MD</au><au>Djoussé, Luc, MD, DSc</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>169</volume><issue>3</issue><spage>371</spage><epage>378.e1</epage><pages>371-378.e1</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Background The American Heart Association (AHA) established recommendations based on 7 ideal health behaviors and factors with the goal of improving cardiovascular health (CVH) and reducing both morbidity and mortality from cardiovascular disease by 20% by 2020. Few studies have investigated their association with subclinical coronary heart disease. We sought to examine whether the 7 AHA CVH metrics were associated with calcified atherosclerotic plaque in the coronary arteries. Methods In a cross-sectional design, we studied 1,731 predominantly white men and women from the National Heart, Lung, and Blood Institute Family Heart Study without prevalent coronary heart disease. Diet was assessed by a semiquantitative food frequency questionnaire. Coronary artery calcium (CAC) was measured by cardiac computed tomography. We defined prevalent CAC using an Agatston score of 100+ and fitted generalized estimating equations to calculate prevalence odds ratios of CAC. Results Mean age was 56.8 years, and 41% were male. The median number of ideal CVH metrics was 3, and no participant met all 7. There was a strong inverse relationship between number of ideal CVH metrics and prevalent CAC. Odds ratios (95% CI) for CAC of 100+ were 1.0 (reference), 0.37 (0.29-0.45), 0.35 (0.26-0.44), and 0.27 (0.20-0.36) among subjects with 0 to 1, 2, 3, and 4+ ideal CVH metrics, respectively ( P = .0001), adjusting for sex, age, field center, alcohol, income, education, and energy consumption. Conclusions These data demonstrate a strong and graded inverse relationship between AHA ideal CVH metrics and prevalent CAC in adult men and women.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25728727</pmid><doi>10.1016/j.ahj.2014.12.017</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Atherosclerosis Blood Glucose - analysis Blood Pressure Body mass index Cardiovascular Cardiovascular disease Cardiovascular Diseases - mortality Cardiovascular Diseases - physiopathology Cardiovascular Physiological Phenomena Cholesterol Coronary Vessels - pathology Cross-Sectional Studies Epidemiology Family medical history Female Glucose Health Behavior Health care Health risk assessment Health Status Heart Humans Hypertension Laboratories Male Middle Aged Mortality Nutrition research Physical fitness Plaque, Atherosclerotic - epidemiology Population Public health Questionnaires Smoking Studies Vascular Calcification - pathology |
| title | Association of ideal cardiovascular health and calcified atherosclerotic plaque in the coronary arteries: The National Heart, Lung, and Blood Institute Family Heart Study |
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