The nature of human sperm head vacuoles: a systematic literature review
Motile sperm organelle morphology examination (MSOME) involves the use of differential interference contrast microscopy (also called Nomarski contrast) at high magnification (at least 6300x) to improve the observation of live human spermatozoa. In fact, this technique evidences sperm head vacuoles t...
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| Veröffentlicht in: | Basic and Clinical Andrology 2013-08, Vol.23 (1), p.3-3, Article 3 |
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| container_title | Basic and Clinical Andrology |
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| creator | Boitrelle, Florence Guthauser, Bruno Alter, Laura Bailly, Marc Wainer, Robert Vialard, François Albert, Martine Selva, Jacqueline |
| description | Motile sperm organelle morphology examination (MSOME) involves the use of differential interference contrast microscopy (also called Nomarski contrast) at high magnification (at least 6300x) to improve the observation of live human spermatozoa. In fact, this technique evidences sperm head vacuoles that are not necessarily seen at lower magnifications - particularly if the vacuoles are small (i.e. occupying |
| doi_str_mv | 10.1186/2051-4190-23-3 |
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In fact, this technique evidences sperm head vacuoles that are not necessarily seen at lower magnifications - particularly if the vacuoles are small (i.e. occupying <4% of the sperm head's area). However, a decade after MSOME's introduction, it is still not clear whether sperm head vacuoles are nuclear, acrosomal and/or membrane-related in nature. In an attempt to clarify this debate, we performed a systematic literature review in accordance with the PRISMA guidelines. The PubMed database was searched from 2001 onwards with the terms "MSOME", "human sperm vacuoles", "high-magnification, sperm". Out of 180 search results, 21 relevant English-language publications on the nature of human sperm head vacuoles were finally selected and reviewed. Our review of the literature prompted us to conclude that sperm-head vacuoles are nuclear in nature and are related to chromatin condensation failure and (in some cases) sperm DNA damage.</description><identifier>ISSN: 2051-4190</identifier><identifier>ISSN: 1166-2654</identifier><identifier>EISSN: 2051-4190</identifier><identifier>DOI: 10.1186/2051-4190-23-3</identifier><identifier>PMID: 25780567</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Chromatin ; Physiological aspects ; Review ; Spermatozoa ; Vacuoles</subject><ispartof>Basic and Clinical Andrology, 2013-08, Vol.23 (1), p.3-3, Article 3</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>Boitrelle et al.; licensee BioMed Central Ltd. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b475t-174287cf51c1302caba2bbc29f111fedc7cb8eab9080b44014357c8540650c853</citedby><cites>FETCH-LOGICAL-b475t-174287cf51c1302caba2bbc29f111fedc7cb8eab9080b44014357c8540650c853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346294/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25780567$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boitrelle, Florence</creatorcontrib><creatorcontrib>Guthauser, Bruno</creatorcontrib><creatorcontrib>Alter, Laura</creatorcontrib><creatorcontrib>Bailly, Marc</creatorcontrib><creatorcontrib>Wainer, Robert</creatorcontrib><creatorcontrib>Vialard, François</creatorcontrib><creatorcontrib>Albert, Martine</creatorcontrib><creatorcontrib>Selva, Jacqueline</creatorcontrib><title>The nature of human sperm head vacuoles: a systematic literature review</title><title>Basic and Clinical Andrology</title><addtitle>Basic Clin Androl</addtitle><description>Motile sperm organelle morphology examination (MSOME) involves the use of differential interference contrast microscopy (also called Nomarski contrast) at high magnification (at least 6300x) to improve the observation of live human spermatozoa. 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In fact, this technique evidences sperm head vacuoles that are not necessarily seen at lower magnifications - particularly if the vacuoles are small (i.e. occupying <4% of the sperm head's area). However, a decade after MSOME's introduction, it is still not clear whether sperm head vacuoles are nuclear, acrosomal and/or membrane-related in nature. In an attempt to clarify this debate, we performed a systematic literature review in accordance with the PRISMA guidelines. The PubMed database was searched from 2001 onwards with the terms "MSOME", "human sperm vacuoles", "high-magnification, sperm". Out of 180 search results, 21 relevant English-language publications on the nature of human sperm head vacuoles were finally selected and reviewed. 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| source | Springer Nature - Complete Springer Journals; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | Chromatin Physiological aspects Review Spermatozoa Vacuoles |
| title | The nature of human sperm head vacuoles: a systematic literature review |
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