Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency

Telomeres are specialized structures providing chromosome integrity during cellular division along with protection against premature senescence and apoptosis. Accelerated telomere attrition in patients with myelodysplastic syndrome (MDS) occurs by an undefined mechanism. Although the MDS clone origi...

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Veröffentlicht in:	Leukemia 2013-04, Vol.27 (4), p.897-906
Hauptverfasser:	Yang, L, Mailloux, A, Rollison, D E, Painter, J S, Maciejewski, J, Paquette, R L, Loughran, T P, McGraw, K, Makishima, H, Radhakrishnan, R, Wei, S, Ren, X, Komrokji, R, List, A F, Epling-Burnette, P K
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554 631/80/103/560 631/80/304 692/699/67/1990/1673 Adolescent Adult Age Aged Aged, 80 and over Apoptosis Attrition Bone marrow Bromodeoxyuridine Cancer Cancer Research Case-Control Studies CD3 antigen Cell Proliferation Cellular structure Chromosomes Cloning Copy number Critical Care Medicine Development and progression Diagnosis Enzymatic activity Female Gene deletion Gene expression Hematology Homeostasis Humans Immunological memory Immunology Intensive Internal Medicine Leukemia Life span Lymphocytes Lymphocytes T Male Medicine Medicine & Public Health Memory cells Middle Aged Mutation Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - enzymology Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - immunology Oncology original-article Physiological aspects Ribonucleic acid RNA RNA-directed DNA polymerase Senescence Signal transduction T cells T-Lymphocytes - immunology Telomerase Telomerase - genetics Telomerase - metabolism Telomerase reverse transcriptase Telomere Telomeres Yeast Young Adult
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