CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival
Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expr...
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| Veröffentlicht in: | Journal of clinical pathology 2015-03, Vol.68 (3), p.200-205 |
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| creator | Chong, Tsung Wen Goh, Fera Yiqian Sim, Mei Yi Huang, Hong Hong Thike, Daw Aye Aye Lim, Weng Khong Teh, Bin Tean Tan, Puay Hoon |
| description | Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ2/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan–Meier method and compared using Cox regression analysis. Results Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival. Conclusions CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes. |
| doi_str_mv | 10.1136/jclinpath-2014-202735 |
| format | Article |
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Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ2/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan–Meier method and compared using Cox regression analysis. Results Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival. Conclusions CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.</description><identifier>ISSN: 0021-9746</identifier><identifier>EISSN: 1472-4146</identifier><identifier>DOI: 10.1136/jclinpath-2014-202735</identifier><identifier>PMID: 25477528</identifier><identifier>CODEN: JCPAAK</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Aged ; Antigens ; Antigens, CD1d - analysis ; Antigens, CD1d - genetics ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Cancer ; Carcinoma, Renal Cell - genetics ; Carcinoma, Renal Cell - immunology ; Carcinoma, Renal Cell - mortality ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - therapy ; Chi-Square Distribution ; Disease Progression ; Disease-Free Survival ; Female ; Gangrene ; Gene expression ; Gene Expression Profiling - methods ; Humans ; Immunohistochemistry ; Immunotherapy ; Kaplan-Meier Estimate ; Kidney Neoplasms - genetics ; Kidney Neoplasms - immunology ; Kidney Neoplasms - mortality ; Kidney Neoplasms - pathology ; Kidney Neoplasms - therapy ; Ligands ; Lipids ; Male ; Metastasis ; Middle Aged ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Oligonucleotide Array Sequence Analysis ; Original ; Predictive Value of Tests ; Proportional Hazards Models ; Retrospective Studies ; Risk Factors ; Software ; T cell receptors ; Time Factors ; Tissue Array Analysis ; Treatment Outcome ; Tumors ; Up-Regulation</subject><ispartof>Journal of clinical pathology, 2015-03, Vol.68 (3), p.200-205</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b583t-ae9547337a72b44f9fbefde76265c4b42f66972867fbfbcbe758b676be84a6f43</citedby><cites>FETCH-LOGICAL-b583t-ae9547337a72b44f9fbefde76265c4b42f66972867fbfbcbe758b676be84a6f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jcp.bmj.com/content/68/3/200.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://jcp.bmj.com/content/68/3/200.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>114,115,230,314,727,780,784,885,3196,23571,27924,27925,53791,53793,77600,77631</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25477528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chong, Tsung Wen</creatorcontrib><creatorcontrib>Goh, Fera Yiqian</creatorcontrib><creatorcontrib>Sim, Mei Yi</creatorcontrib><creatorcontrib>Huang, Hong Hong</creatorcontrib><creatorcontrib>Thike, Daw Aye Aye</creatorcontrib><creatorcontrib>Lim, Weng Khong</creatorcontrib><creatorcontrib>Teh, Bin Tean</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><title>CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival</title><title>Journal of clinical pathology</title><addtitle>J Clin Pathol</addtitle><description>Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ2/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan–Meier method and compared using Cox regression analysis. Results Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival. Conclusions CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.</description><subject>Aged</subject><subject>Antigens</subject><subject>Antigens, CD1d - analysis</subject><subject>Antigens, CD1d - genetics</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer</subject><subject>Carcinoma, Renal Cell - genetics</subject><subject>Carcinoma, Renal Cell - immunology</subject><subject>Carcinoma, Renal Cell - mortality</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - therapy</subject><subject>Chi-Square Distribution</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gangrene</subject><subject>Gene expression</subject><subject>Gene Expression Profiling - methods</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Immunotherapy</subject><subject>Kaplan-Meier Estimate</subject><subject>Kidney Neoplasms - genetics</subject><subject>Kidney Neoplasms - immunology</subject><subject>Kidney Neoplasms - mortality</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - therapy</subject><subject>Ligands</subject><subject>Lipids</subject><subject>Male</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Neoplasm Staging</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>Original</subject><subject>Predictive Value of Tests</subject><subject>Proportional Hazards Models</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Software</subject><subject>T cell receptors</subject><subject>Time Factors</subject><subject>Tissue Array Analysis</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>0021-9746</issn><issn>1472-4146</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkk-PFCEQxYnRuOPqR9CQePFgK9A0MBeTzfg32cSLngnQxTaTbmihe9TEDy-TWSfqRS9FQv3q5VE8hB5T8oLSVrzcuzHE2SxDwwjltTDZdnfQhnLJGk65uIs2hDDabCUXF-hBKXtCaCtpex9dsI5L2TG1QT92r2mP4ducoZSQIg4RZ4hmxA7GWkx2IabJ4FCwKSW5YBbo8dewDHgINwPkio9mLoBz7ZTneE4p11tnooPclBlc8MFhE3ucDpBNVS1rPoSDGR-ie96MBR7dnpfo89s3n3bvm-uP7z7srq4b26l2aQxsq9-2lUYyy7nfegu-BymY6By3nHkhtpIpIb311lmQnbJCCguKG-F5e4lenXTn1U7QO4hL9aHnHCaTv-tkgv6zE8Ogb9JB85Z3W8WqwLNbgZy-rFAWPYVyXJCJkNaiqSJKMNa18t-o6ATh1Z2o6NO_0H1ac919paSihCvJj-a7E-VyKiWDP_umRB-joM9R0Mco6FMU6tyT3x99nvr19xUgJ8BO-__U_AmyBcQU</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Chong, Tsung Wen</creator><creator>Goh, Fera Yiqian</creator><creator>Sim, Mei Yi</creator><creator>Huang, Hong Hong</creator><creator>Thike, Daw Aye Aye</creator><creator>Lim, Weng Khong</creator><creator>Teh, Bin Tean</creator><creator>Tan, Puay Hoon</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20150301</creationdate><title>CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival</title><author>Chong, Tsung Wen ; Goh, Fera Yiqian ; Sim, Mei Yi ; Huang, Hong Hong ; Thike, Daw Aye Aye ; Lim, Weng Khong ; Teh, Bin Tean ; Tan, Puay Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b583t-ae9547337a72b44f9fbefde76265c4b42f66972867fbfbcbe758b676be84a6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Antigens</topic><topic>Antigens, CD1d - analysis</topic><topic>Antigens, CD1d - genetics</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer</topic><topic>Carcinoma, Renal Cell - genetics</topic><topic>Carcinoma, Renal Cell - immunology</topic><topic>Carcinoma, Renal Cell - mortality</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - therapy</topic><topic>Chi-Square Distribution</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gangrene</topic><topic>Gene expression</topic><topic>Gene Expression Profiling - methods</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Immunotherapy</topic><topic>Kaplan-Meier Estimate</topic><topic>Kidney Neoplasms - genetics</topic><topic>Kidney Neoplasms - immunology</topic><topic>Kidney Neoplasms - mortality</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - therapy</topic><topic>Ligands</topic><topic>Lipids</topic><topic>Male</topic><topic>Metastasis</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local</topic><topic>Neoplasm Staging</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>Original</topic><topic>Predictive Value of Tests</topic><topic>Proportional Hazards Models</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Software</topic><topic>T cell receptors</topic><topic>Time Factors</topic><topic>Tissue Array Analysis</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chong, Tsung Wen</creatorcontrib><creatorcontrib>Goh, Fera Yiqian</creatorcontrib><creatorcontrib>Sim, Mei Yi</creatorcontrib><creatorcontrib>Huang, Hong Hong</creatorcontrib><creatorcontrib>Thike, Daw Aye Aye</creatorcontrib><creatorcontrib>Lim, Weng Khong</creatorcontrib><creatorcontrib>Teh, Bin Tean</creatorcontrib><creatorcontrib>Tan, Puay Hoon</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chong, Tsung Wen</au><au>Goh, Fera Yiqian</au><au>Sim, Mei Yi</au><au>Huang, Hong Hong</au><au>Thike, Daw Aye Aye</au><au>Lim, Weng Khong</au><au>Teh, Bin Tean</au><au>Tan, Puay Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival</atitle><jtitle>Journal of clinical pathology</jtitle><addtitle>J Clin Pathol</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>68</volume><issue>3</issue><spage>200</spage><epage>205</epage><pages>200-205</pages><issn>0021-9746</issn><eissn>1472-4146</eissn><coden>JCPAAK</coden><abstract>Aims We hypothesised that CD1d expression in renal cell carcinoma (RCC) may play a role in modifying the host immune response. Our aims were to investigate the expression of CD1d and to correlate this with histopathology and clinical outcomes in a cohort study of patients with RCC. Methods Gene expression and tissue microarray studies on a panel of RCC tissue were performed. Clinicopathological correlation was analysed using χ2/Fisher's exact test. Relapse-free survival, cancer-specific survival and overall survival were calculated for both CD1d high and low expressors. Survival outcomes were estimated with the Kaplan–Meier method and compared using Cox regression analysis. Results Gene expression microarray showed significant expression of CD1d in RCC versus normal renal tissue. By immunohistochemistry, we found that CD1d expression significantly associated with tumour stage/grade, higher relapse rates, poorer cancer-specific and overall survival. Conclusions CD1d expression on RCC correlated with aggressive disease and poorer clinical outcomes.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>25477528</pmid><doi>10.1136/jclinpath-2014-202735</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical pathology, 2015-03, Vol.68 (3), p.200-205 |
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| subjects | Aged Antigens Antigens, CD1d - analysis Antigens, CD1d - genetics Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Cancer Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - immunology Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - therapy Chi-Square Distribution Disease Progression Disease-Free Survival Female Gangrene Gene expression Gene Expression Profiling - methods Humans Immunohistochemistry Immunotherapy Kaplan-Meier Estimate Kidney Neoplasms - genetics Kidney Neoplasms - immunology Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidney Neoplasms - therapy Ligands Lipids Male Metastasis Middle Aged Neoplasm Recurrence, Local Neoplasm Staging Oligonucleotide Array Sequence Analysis Original Predictive Value of Tests Proportional Hazards Models Retrospective Studies Risk Factors Software T cell receptors Time Factors Tissue Array Analysis Treatment Outcome Tumors Up-Regulation |
| title | CD1d expression in renal cell carcinoma is associated with higher relapse rates, poorer cancer-specific and overall survival |
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