Exendin-4 protects against post-myocardial infarction remodelling via specific actions on inflammation and the extracellular matrix

Glucagon-like peptide-1 (GLP-1) is an insulin-releasing hormone clinically exploited for glycaemic control in diabetes, which also confers acute cardioprotection and benefits in experimental/clinical heart failure. We specifically investigated the role of the GLP-1 mimetic, exendin-4, in post-myocar...

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Veröffentlicht in:	Basic research in cardiology 2015-03, Vol.110 (2), p.20, Article 20
Hauptverfasser:	Robinson, Emma, Cassidy, Roslyn S., Tate, Mitchel, Zhao, Youyou, Lockhart, Samuel, Calderwood, Danielle, Church, Rachel, McGahon, Mary K., Brazil, Derek P., McDermott, Barbara J., Green, Brian D., Grieve, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cardiology Disease Models, Animal Exenatide Extracellular Matrix - drug effects Extracellular Matrix - metabolism Female Immunohistochemistry In Situ Nick-End Labeling Inflammation - metabolism Inflammation - pathology Medicine Medicine & Public Health Mice Mice, Inbred C57BL Myocardial Infarction - metabolism Myocardial Infarction - pathology Original Contribution Peptides - pharmacology Rats Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Venoms - pharmacology Ventricular Remodeling - drug effects Ventricular Remodeling - physiology
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