Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity

•Administration orally with ZnO nanoparticles (Nano-ZnO) caused disruption of ER structure and function in hepatocytes, resulting in ER stress.•Nano-ZnO also caused ER stress-associated genes and proteins upregulation and hepatocyte apoptosis.•ER stress may be involved in Nano-ZnO-induced liver inju...

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Veröffentlicht in:	Toxicology letters 2015-04, Vol.234 (1), p.40-49
Hauptverfasser:	Yang, Xia, Shao, Huali, Liu, Weirong, Gu, Weizhong, Shu, Xiaoli, Mo, Yiqun, Chen, Xuejun, Zhang, Qunwei, Jiang, Mizu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood Animals Apoptosis Aspartate Aminotransferases - blood Blotting, Western Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism DNA-Binding Proteins - analysis eIF-2 Kinase - analysis Endoplasmic reticulum stress Endoplasmic Reticulum Stress - drug effects Exposure Glutathione - analysis Heat-Shock Proteins - analysis Injuries Liver Liver injury Male Membrane Glycoproteins - analysis Mice Mice, Inbred C57BL Microscopy, Electron, Transmission Nano-ZnO Nanoparticles - toxicity Nanostructure Oxidative stress Phosphorylation Protein Disulfide-Isomerases - analysis Random Allocation Real-Time Polymerase Chain Reaction Regulatory Factor X Transcription Factors RNA - chemistry RNA - genetics Stresses Transaminases Transcription Factor CHOP - analysis Transcription Factors - analysis X-Box Binding Protein 1 Zinc Oxide - toxicity
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