Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies

Background Reduced CYP2D6 metabolism and low Z-endoxifen (ENDX) concentrations may increase the risk of breast cancer recurrence in tamoxifen (TAM)-treated women. Little is known regarding the differences between TAM and ENDX murine pharmacokinetics or the effect of administration route on plasma co...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2014-12, Vol.74 (6), p.1271-1278
Hauptverfasser:	Reid, Joel M., Goetz, Matthew P., Buhrow, Sarah A., Walden, Chad, Safgren, Stephanie L., Kuffel, Mary J., Reinicke, Kathryn E., Suman, Vera, Haluska, Paul, Hou, Xiaonan, Ames, Matthew M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic agents Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - pharmacokinetics Area Under Curve Biological and medical sciences Cancer Research Cytochrome P-450 CYP2D6 - metabolism Dose-Response Relationship, Drug Female Injections, Subcutaneous Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred BALB C Mice, Nude Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Tamoxifen - administration & dosage Tamoxifen - analogs & derivatives Tamoxifen - pharmacokinetics
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