Peroxisome Proliferator–Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP‐Activated Protein Kinase

Objective AMP‐activated protein kinase (AMPK) inhibits chondrocyte procatabolic responses to inflammation and biomechanical injury. This study was undertaken to test the hypothesis that peroxisome proliferator–activated receptor γ coactivator 1α (PGC‐1α) and FoxO3A, 2 major AMPK downstream targets,...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2014-11, Vol.66 (11), p.3073-3082
Hauptverfasser:	Zhao, Xianling, Petursson, Freyr, Viollet, Benoit, Lotz, Martin, Terkeltaub, Robert, Liu‐Bryan, Ru
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism AMP-Activated Protein Kinases - deficiency AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Catalase - metabolism Cells, Cultured Chondrocytes - drug effects Chondrocytes - metabolism Chondrocytes - pathology Disease Models, Animal Forkhead Box Protein O3 Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Humans Menisci, Tibial - surgery Mice Mice, Inbred C57BL Osteoarthritis - etiology Osteoarthritis - metabolism Osteoarthritis - pathology Oxidative Stress - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA, Small Interfering - pharmacology Superoxide Dismutase - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcription Factors - metabolism Transfection
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