Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma

AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL pat...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2015-02, Vol.21 (8), p.2433-2442
Hauptverfasser:	Xia, Bing, Zhang, Le, Guo, Shan-Qi, Li, Xiao-Wu, Qu, Fu-Lian, Zhao, Hai-Feng, Zhang, Lian-Yu, Sun, Bao-Cun, You, James, Zhang, Yi-Zhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Case-Control Studies Chi-Square Distribution China Clinical Trials Study diffus Disease-Free Survival Female gastrointestinal Gastrointestinal Neoplasms - chemistry Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - mortality Gastrointestinal Neoplasms - pathology Gastrointestinal Neoplasms - therapy Hospitals, University Humans Immunohistochemistry Kaplan-Meier Estimate Lymphoma, Large B-Cell, Diffuse - chemistry Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - therapy Male Middle Aged Multivariate Analysis MYC BCL-2 Survival Primary Neoplasm Staging Predictive Value of Tests Proportional Hazards Models Proto-Oncogene Proteins c-bcl-2 - analysis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-myc - analysis Proto-Oncogene Proteins c-myc - genetics Real-Time Polymerase Chain Reaction Risk Factors RNA, Messenger - analysis Time Factors Treatment Outcome Young Adult
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